The hydrothermal reactions of In(NO₃)₃·2H₂O with 5-fluoroisophthalic acid or 1,3,5-benzenetricarboxylic acid produce two new In(III)-based coordination polymers [H₂NMe₂]⁺[In{(O₂C)₂FC₆H₃}₂]⁻(H₂O)₄ (1) and [In₃{(O₂C)₃C₆H₃}₂(H₂O)₁₀]³⁺[(NO₃)₃]³⁻ (H₂O)₂ (2). A green hand-grinding technology was used to decrease the particle sizes of 1 and 2 to generate nanoscale samples (nano 1 and nano 2). Furthermore, the inhibitory activity of nano 1–2 against a series of cancer cells was evaluated with Cell Counting Kit-8 assays. Results indicated that the nanos showed the highest selectivity on KNS-81 cells. In particular, nano 1 had the IC₅₀ value of 1.64 ± 0.06 mΜ. RT-PCR was performed to detect the relative expression levels of p53, nf-κb, and tnf-α after treatment. Nano 1 could significantly increase the expression levels of p53, nf-κb, and tnf-α apoptotic genes and exert antitumor activity. Compared with nano 2, nano 1 has the potential to be developed into an anticancer drug that targets human gliomas.

中文翻译：

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两种新型晶体纳米级In（III）配位聚合物：晶体结构和胶质瘤细胞生长抑制。

In（NO ₃）₃ ·2H ₂ O与5-氟间苯二甲酸或1,3,5-苯三甲酸的水热反应产生两种新的基于In（III）的配位聚合物[H ₂ NMe ₂ ] ⁺ [In {（ O ₂ C）₂ FC ₆ H ₃ } ₂ ] ^-（H ₂ O）₄（1）和[In ₃ {（O ₂ C）₃ C ₆ H ₃ } ₂（H ₂ O）₁₀ ] ³⁺[（NO ₃）₃ ] ^3-（H ₂ O）₂（2）。使用绿色手工研磨技术来减小1和2的粒度，以生成纳米级样品（纳米1和纳米2）。此外，纳米的抑制活性1 - 2针对一系列癌细胞用细胞计数试剂盒8测定法进行评价。结果表明，纳米颗粒对KNS-81细胞具有最高的选择性。尤其是nano 1具有IC ₅₀值1.64±0.06mM。治疗后进行RT-PCR检测p53，nf-κb和tnf-α的相对表达水平。Nano 1可以显着增加p53，nf-κb和tnf-α凋亡基因的表达水平，并发挥抗肿瘤活性。与nano 2相比，nano 1有可能发展成为针对人类神经胶质瘤的抗癌药物。