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Determining Haemodynamic Wall Shear Stress in the Rabbit Aorta In Vivo Using Contrast-Enhanced Ultrasound Image Velocimetry.
Annals of Biomedical Engineering ( IF 3.8 ) Pub Date : 2020-03-04 , DOI: 10.1007/s10439-020-02484-2
K Riemer 1 , E M Rowland 1 , C H Leow 1 , M X Tang 1 , P D Weinberg 1
Affiliation  

Abnormal blood flow and wall shear stress (WSS) can cause and be caused by cardiovascular disease. To date, however, no standard method has been established for mapping WSS in vivo. Here we demonstrate wide-field assessment of WSS in the rabbit abdominal aorta using contrast-enhanced ultrasound image velocimetry (UIV). Flow and WSS measurements were made independent of beam angle, curvature or branching. Measurements were validated in an in silico model of the rabbit thoracic aorta with moving walls and pulsatile flow. Mean errors over a cardiac cycle for velocity and WSS were 0.34 and 1.69%, respectively. In vivo time average WSS in a straight segment of the suprarenal aorta correlated highly with simulations (PC = 0.99) with a mean deviation of 0.29 Pa or 5.16%. To assess fundamental plausibility of the measurement, UIV WSS was compared to an analytic approximation derived from the Poiseuille equation; the discrepancy was 17%. Mapping of WSS was also demonstrated in regions of arterial branching. High time average WSS (TAWSSxz = 3.4 Pa) and oscillatory flow (OSIxz = 0.3) were observed near the origin of conduit arteries. In conclusion, we have demonstrated that contrast-enhanced UIV is capable of measuring spatiotemporal variation in flow velocity, arterial wall location and hence WSS in vivo with high accuracy over a large field of view.



中文翻译:

使用对比增强的超声图像测速仪确定体内主动脉的血流动力学壁剪切应力。

异常的血流和壁切应力(WSS)可以引起心血管疾病,也可能由心血管疾病引起。然而,迄今为止,尚未建立用于在体内标测WSS的标准方法。在这里,我们展示了使用对比增强型超声图像测速仪(UIV)进行的兔腹主动脉WSS的广域评估。流量和WSS测量与束角,曲率或分支无关。在具有移动壁和脉动血流的兔胸主动脉的计算机模型中验证了测量结果。在心动周期上,速度和WSS的平均误差分别为0.34和1.69%。体内肾上主动脉直段的平均时间WSS与模拟高度相关(PC = 0.99),平均偏差为0.29 Pa或5.16%。为了评估测量的基本合理性,将UIV WSS与从Poiseuille方程得出的解析近似值进行了比较。差异为17%。WSS的制图也显示在动脉分支区域。 在导管动脉起点附近观察到高时间平均WSS(TAWSS xz  = 3.4 Pa)和振荡流量(OSI xz = 0.3)。总之,我们已经证明,增强对比度的UIV能够在大视野内以高精度测量体内流速,动脉壁位置以及时空WSS的时空变化。

更新日期:2020-03-04
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