In this paper, comparison of ecotoxicological and herbicidal effect of newly synthesized N‑[(phosphono)(aryl)methyl]glycines 1a-g (C-substituted glyphosate derivatives) with pure glyphosate (N-phosphonomethylglycine) (2) was demonstrated. All of tested glyphosate derivatives (1a-g) in contrast to glyphosate, were found to be completely safe for oat (Avena sativa) and classified as not harmful for marine bacteria Aliivibrio fischeri. Compounds 1a-g were also found rather harmless to radish (Raphanus sativus) as compared to N-phosphonomethylglycine, but they were moderately toxic against freshwater crustaceans Heterocypris incongruens. One of synthesized compounds, namely N-[(phosphono)(4-hydroxyphenyl)methyl]glycine (1f) was found to possess stronger herbicidal properties against gallant soldier (Galinsoga parviflora) and common sorrel (Rumex acetosa) when compared to pure glyphosate and demonstrated total death of these weeds being ranked 1 in the European Weed Research Council (EWRC) scale. Considering lower phytotoxicity of compound 1f against cultivated plants and tested microorganisms when compared to pure glyphosate, this aminophosphonate may be good candidate for further, more comprehensive study toward its agrochemical application, especially that this active agent demonstrated much stronger herbicidal properties than N-phosphonomethylglycine.

本文证明了新合成的N -[（膦酰基）（芳基）甲基]甘氨酸1a-g（C取代的草甘膦衍生物）与纯草甘膦（N-膦酰基甲基甘氨酸）的生态毒理和除草效果（2）。与草甘膦相反，所有测试的草甘膦衍生物（1a-g）被发现对燕麦（Avena sativa）而言是完全安全的，并被分类为对海洋细菌Aliivibrio fischeri无害。与氮相比，化合物1a-g还对萝卜无害（Raphanus sativus）。-膦酰基甲基甘氨酸，但它们对淡水甲壳类杂合子Heterocypris incongruens具有中等毒性。与纯草甘膦和草甘膦相比，发现一种合成的化合物，即N -[（膦酰基）（4-羟苯基）甲基]甘氨酸（1f）具有对英勇战士（Galinsoga parviflora）和and浆草（Rumex acetosa）的更强除草性能。证明这些杂草的总死亡在欧洲杂草研究委员会（EWRC）等级中排名第一。考虑降低化合物1f的植物毒性与纯草甘膦相比，这种氨基膦酸盐对栽培植物和受试微生物具有更好的候选能力，尤其是与N-膦酰基甲基甘氨酸相比，具有更强的除草性能。