The main goal of this study was to elucidate the neuron proliferation and cognition improvement effects of steamed and freeze-dried mature silkworm powders (SMSP). Concentrates of 80% methanol extracts from golden silk-SMSP (GS-SMSP) contained 3.6–4.9 times more phytochemicals and 1.8–3.1 times more antioxidant activities and showed significantly higher mouse hippocampal HT22 neuronal cell proliferation effects than those of white jade (WJ)-SMSP. In addition, GS-SMSP was more effective in suppressing scopolamine (SCO)-induced amnesia in the mice than WJ-SMSP. Furthermore, the suppression of SCO-induced amnesia by GS-SMSP in the mice was dose-dependent. The significantly reduced mitochondrial respiratory complex (MitoCom) activities and ATP amounts in the brains of SCO-injected mice were recovered in the mice supplemented with GS-SMSP. Taken together, the results of this study indicate that enhanced mitochondrial function in the brains of mice supplemented with GS-SMSP was the molecular basis of suppression of SCO-induced amnesia in a rodent model.

这项研究的主要目的是阐明蒸熟和冷冻干燥的成熟蚕粉（SMSP）的神经元增殖和认知改善作用。从金丝SMSP（GS-SMSP）中提取的80％甲醇浓缩物所含的植物化学物质和抗氧化活性高3.6-4.9倍，抗氧化活性高1.8-3.1倍，并且小鼠海马HT22神经元细胞的增殖作用明显高于白玉（WJ）。 -SMSP。此外，与WJ-SMSP相比，GS-SMSP在抑制东碱（SCO）引起的小鼠健忘症方面更有效。此外，小鼠中GS-SMSP对SCO诱导的健忘的抑制作用是剂量依赖性的。在补充了GS-SMSP的小鼠中，恢复了SCO注射的小鼠大脑中线粒体呼吸复合物（MitoCom）活性和ATP含量的显着降低。