Dendritic cells function in the immune system to instruct adaptive immune cells to respond accordingly to different threats. While conventional dendritic cells can be subdivided into two main subtypes, termed cDC1s and cDC2s, it is clear that further heterogeneity exists within these subtypes, particularly for cDC2s. Understanding the signals involved in specifying each of these lineages and subtypes thereof is crucial to (i) enable us to determine their specific functions and (ii) put us in a position to be able to target these cells to promote or prevent a specific function in any given disease setting. Although we still have much to learn regarding the specification of these cells, here we review the most recent advances in our understanding of this and highlight some of the next questions for the future.

中文翻译：

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DC命运规范的转录规定。

树突状细胞在免疫系统中发挥功能，指示适应性免疫细胞对不同的威胁做出相应的反应。尽管常规的树突状细胞可以分为两种主要的亚型，分别称为cDC1和cDC2，但是很明显，这些亚型中还存在其他异质性，特别是对于cDC2。了解指定这些谱系及其亚型中的每一个所涉及的信号对于（i）使我们能够确定其特定功能，以及（ii）使我们能够靶向这些细胞以促进或阻止其特定功能至关重要。任何给定的疾病背景。尽管关于这些电池的规格我们仍然有很多要学习的知识，但在这里我们回顾了我们对这些电池的了解的最新进展，并着重指出了未来的一些下一个问题。