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Liquid metal based theranostic nanoplatforms: Application in cancer therapy, imaging and biosensing.
Nanomedicine: Nanotechnology, Biology and Medicine ( IF 5.4 ) Pub Date : 2020-03-06 , DOI: 10.1016/j.nano.2020.102175
Sanjay Kulkarni 1 , Abhijeet Pandey 1 , Srinivas Mutalik 1
Affiliation  

Liquid metals in recent years have grabbed the attention of researchers due to their expanded applicability not only in the field of therapeutics but also in theranostic. Acknowledged as a nuclear medicine due to its radioactivity, Gallium finds its widespread application in disorders of bone, calcium metabolism, and cancer. The present article deals with the advancement of gallium based nanoplatforms for therapy, imaging, and biosensing of cancers. The article describes the gallium based nanoconjugates and furnishes one's understanding of various therapeutic approaches such as photothermal therapy, sonodynamic therapy, radiotherapy, and immunotherapy along with various imaging platforms and biosensing platforms. A brief section related to patents on gallium based nanoplatforms in cancer has been included along with various molecular docking and simulation studies done on gallium. The recent advancement with respect to drug delivery gives an insight into the future perspective of gallium based nanoplatforms in the field of cancer theranostic.

中文翻译:

液态金属基治疗纳米平台:在癌症治疗,成像和生物传感中的应用。

近年来,液态金属不仅在治疗领域而且在治疗医学领域都得到了广泛应用,因此引起了研究人员的关注。由于其放射性而被公认为核医学,镓在骨骼,钙代谢和癌症疾病中得到了广泛的应用。本文讨论了基于镓的纳米平台在癌症的治疗,成像和生物传感方面的进展。本文介绍了基于镓的纳米共轭物,并提供了对各种治疗方法(例如光热疗法,声波动力疗法,放射疗法和免疫疗法)以及各种成像平台和生物传感平台的理解。与癌症中基于镓的纳米平台的专利有关的简短部分以及在镓上进行的各种分子对接和模拟研究均已包括在内。药物输送方面的最新进展使人们对癌症治疗治疗领域中基于镓的纳米平台的未来前景有了深刻的了解。
更新日期:2020-03-06
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