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Pulmonary Hypertension by the Method of Paul Wood
Chest ( IF 9.6 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.chest.2020.02.035
John H Newman 1
Affiliation  

A physiological approach to the analysis of hemodynamic data in pulmonary hypertension (PH) has the advantage of reducing the large number (well over 100) of potential causal illnesses into four simple mechanisms. A fifth condition is composed of mixtures of the four basic mechanisms. This approach was beautifully described by Paul Wood, the great cardiologist whose name is given to the units of pulmonary vascular resistance (PVR), Wood units. This approach uses well understood physiological contributions to pulmonary vascular pressure. It is powerful, the major uncertainty being in determination of the magnitude of each mechanism in patients that have mixed pulmonary hypertension of several causes. It also makes sense of the occasionally awkward clustering of conditions in the clinical classification of the World Symposium, which omits pulmonary vasoconstriction, hyperkinetic states and the highly prevalent condition of "mixed" PH. This method of analysis will be described and demonstrated, much as Wood did in his writings. The method is useful in the office, the ICU and in consultation. A basic message from this approach is that correct assessment requires measurement of each of the three major inputs, pulmonary arterial pressure (Ppa), pulmonary artery wedge pressure (Pwedge) and cardiac output, (CO). Some cases also need left ventricular end diastolic pressure (LVEDP). Other data contributing to analysis will be discussed in each condition. A key to avoiding mistakes is to always remember that PH is simply an elevation in pressure and is not inherently diagnostic of cause.

中文翻译:

Paul Wood 方法的肺动脉高压

分析肺动脉高压 (PH) 血流动力学数据的生理学方法具有将大量(超过 100 种)潜在病因减少为四种简单机制的优势。第五个条件由四种基本机制的混合组成。伟大的心脏病专家保罗伍德 (Paul Wood) 对这种方法进行了精美的描述,他的名字以肺血管阻力 (PVR) 为单位,即伍德单位。这种方法使用众所周知的对肺血管压力的生理贡献。它是强大的,主要的不确定性在于确定具有多种原因的混合性肺动脉高压的患者中每种机制的程度。这也说明了世界研讨会临床分类中偶尔出现的尴尬的情况聚类,它忽略了肺血管收缩、多动状态和“混合”PH 的高度流行状况。这种分析方法将被描述和展示,就像伍德在他的著作中所做的那样。该方法在办公室、ICU 和会诊中很有用。这种方法的基本信息是正确的评估需要测量三个主要输入中的每一个,肺动脉压 (Ppa)、肺动脉楔压 (Pwedge) 和心输出量 (CO)。有些病例还需要左心室舒张末压 (LVEDP)。其他有助于分析的数据将在每个条件下讨论。避免错误的关键是始终记住 PH 只是压力升高,而不是本质上的原因诊断。这种方法的基本信息是正确的评估需要测量三个主要输入中的每一个,肺动脉压 (Ppa)、肺动脉楔压 (Pwedge) 和心输出量 (CO)。有些病例还需要左心室舒张末压 (LVEDP)。其他有助于分析的数据将在每个条件下讨论。避免错误的关键是始终记住 PH 只是压力升高,而不是本质上的原因诊断。这种方法的基本信息是正确的评估需要测量三个主要输入中的每一个,肺动脉压 (Ppa)、肺动脉楔压 (Pwedge) 和心输出量 (CO)。有些病例还需要左心室舒张末压 (LVEDP)。其他有助于分析的数据将在每个条件下讨论。避免错误的关键是始终记住 PH 只是压力升高,而不是本质上的原因诊断。
更新日期:2020-09-01
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