The aim of this study was to determine prevalence and possible clinical predictors of suboptimal peak inspiratory flow rate (PIFR) with different dry powder inhalers. PIFR was measured across all resistance ranges of In-Check Dial® in 180 chronic obstructive pulmonary disease (COPD) subjects before hospital discharge. COPD subjects were defined as suboptimal if measured PIFR was suboptimal with any resistance representative of specific inhalers (R1-R5). Demographics and clinical data were collected, including COPD Assessment Test (CAT) and modified Medical Research Council (mMRC) scores, Global Initiative for Obstructive Lung Disease (GOLD) stage spirometry by Spirodoc® and peak flow meter measurements with portable peak inspiratory and expiratory flow meters. All were correlated with In-Check Dial PIFRs. Suboptimal PIFR was 44.44% prevalent in COPD subjects. 55% of the suboptimal cohort was female which represent 57.14% of the total female population in the study. The distribution of suboptimal PIFR included 43.75% with R1, 67.5% with R2, 100% with R3, 13.75% with R4, and 21.25% with R5. In the suboptimal cohort, CAT score was significantly higher and spirometry demonstrated significantly lower lung function results compared to the optimal cohort (p < 0.05). The only parameter to show strong and moderate correlation with In-Check Dial PIFRs was PIFR measured by peak flow meter (p < 0.001). Suboptimal PIFR is common among COPD subjects at hospital discharge. Female gender and peak flow meter PIFR was the only predictor of suboptimal PIFR. Inhaler therapy for COPD patients must be personalized based on simple routine measurement of In-Check Dial PIFRs or peak flow meter PIFR to optimize clinical benefits .

中文翻译：

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COPD患者的最佳吸气峰值流速的患病率和预测因素。

这项研究的目的是确定不同干粉吸入器的次最佳峰值吸气流速（PIFR）的患病率和可能的临床预测因素。在出院前，对180位慢性阻塞性肺疾病（COPD）受试者在In-CheckDial®的所有抵抗范围内测量PIFR。如果测量的PIFR在任何代表特定吸入器（R1-R5）的抵抗力下均次优，则将COPD受试者定义为次优。收集了人口统计学和临床​​数据，包括COPD评估测试（CAT）和改良的医学研究理事会（mMRC）得分，通过Spirodoc®进行的全球阻塞性肺疾病倡议（GOLD）阶段肺活量测定以及带有便携式峰值吸气和呼气流量的峰值流量计测量米。所有这些都与检查中拨号PIFR相关。最佳PIFR为44。在COPD受试者中占44％。55％的次优人群是女性，占研究中女性总人数的57.14％。次优PIFR的分布包括：R1为43.75％，R2为67.5％，R3为100％，R4为13.75％，R5为21.25％。在次优队列中，与最佳队列相比，CAT评分显着较高，肺活量测定显示肺功能结果显着较低（p <0.05）。唯一与In-Check Dial PIFR显示强而适中的相关性的参数是峰值流量计测量的PIFR（p <0.001）。在出院时COPD患者中PIFR欠佳是常见的。女性性别和峰值流量计PIFR是次优PIFR的唯一预测因子​​。