Macromolecules comprise only 2% of vitreous, yet are responsible for its gel state, transparency, and physiologic function(s) within the eye. Myopia and aging alter collagen and hyaluronan association causing concurrent gel liquefaction and fibrous degeneration. The resulting vitreous opacities and collapse of the vitreous body during posterior vitreous detachment are the most common causes for the visual phenomenon of vitreous floaters. Previously considered innocuous, the vitreous opacities that cause floaters sometimes impact vision by profoundly degrading contrast sensitivity function and impairing quality-of-life. While many people adapt to vitreous floaters, clinically significant cases can be diagnosed with Vision Degrading Myodesopsia based upon echographic assessment of vitreous structure and by measuring contrast sensitivity function. Perhaps due to the ubiquity of floaters, the medical profession has to date largely ignored the plight of those with Vision Degrading Myodesopsia. Improved diagnostics will enable better disease staging and more accurate identification of severe cases that merit therapy. YAG laser treatments may occasionally be slightly effective, but vitrectomy is currently the definitive cure. Future developments will usher in more informative diagnostic approaches as well as safer and more effective therapeutic strategies. Improved laser treatments, new pharmacotherapies, and possibly non-invasive optical corrections are exciting new approaches to pursue. Ultimately, enhanced understanding of the underlying pathogenesis of Vision Degrading Myodesopsia should result in prevention, the ultimate goal of modern Medicine.

大分子仅占玻璃体的2％，但仍负责其凝胶状态，透明度和眼内的生理功能。近视和衰老改变了胶原蛋白和透明质酸的结合，导致并发的凝胶液化和纤维变性。在玻璃体后脱离时产生的玻璃体混浊和玻璃体塌陷是玻璃体漂浮物视觉现象的最常见原因。以前被认为是无害的，导致漂浮物的玻璃体混浊有时会通过严重降低对比度敏感度功能和损害生活质量来影响视力。尽管许多人适应玻璃体漂浮物，但临床上可诊断为视力退化性肌强直的重要病例基于对玻璃体结构的超声检查评估和通过测量对比敏感度函数。也许由于浮游生物的普遍存在，迄今为止，医学界已经很大程度上忽略了视力退化性肌弱视患者的困境。改进的诊断功能将使更好的疾病分期和更准确地识别值得治疗的严重病例。YAG激光治疗有时可能会稍微有效，但是玻璃体切除术目前是绝对的治疗方法。未来的发展将迎来更多有用的诊断方法以及更安全，更有效的治疗策略。改进的激光治疗，新的药物治疗以及可能的非侵入性光学矫正是令人兴奋的新方法。最终，