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Detectable HIV-1 in semen in individuals with very low blood viral loads.
Virology Journal ( IF 4.8 ) Pub Date : 2020-03-05 , DOI: 10.1186/s12985-020-01300-6
Samuel Mundia Kariuki 1, 2, 3 , Philippe Selhorst 4, 5 , Jennifer Norman 6 , Karen Cohen 6 , Kevin Rebe 7, 8 , Carolyn Williamson 4, 9, 10 , Jeffrey R Dorfman 1, 11
Affiliation  

Several reports indicate that a portion (5–10%) of men living with HIV-1 intermittently shed HIV-1 RNA into seminal plasma while on long term effective antiretroviral therapy (ART). This is highly suggestive of an HIV-1 reservoir in the male genital tract. However, the status of this reservoir in men living with HIV-1 who are not under treatment is underexplored and has implications for understanding the origins and evolution of the reservoir. Forty-three HIV-1 positive, antiretroviral therapy naïve study participants attending a men’s health clinic were studied. Semen viral loads and blood viral loads were generally correlated, with semen viral loads generally detected in individuals with blood viral loads > 10,000 cp/ml. However, we found 1 individual with undetectable viral loads (<20cp/ml) and 2 individuals with very low blood viral load (97 and 333cp/ml), but with detectable HIV-1 in semen (485–1157 copies/semen sample). Blood viral loads in the first individual were undetectable when tested three times over the prior 5 years. Semen HIV-1 viral loads are usually related to blood viral loads, as we confirm. Nonetheless, this was not true in a substantial minority of individuals suggesting unexpectedly high levels of replication in the male genital tract in a few individuals, despite otherwise effective immune control. This may reflect establishment of a local reservoir of HIV-1 populations.

中文翻译:

血液病毒载量极低的人精液中可检测到HIV-1。

几份报告表明,在长期有效的抗逆转录病毒疗法(ART)期间,有一部分(5-10%)的HIV-1男性间歇性地使HIV-1 RNA进入精浆。这强烈暗示在男性生殖道中有一个HIV-1储库。但是,该水库在未接受治疗的HIV-1男性患者中的状况尚未得到充分研究,对理解水库的起源和演变具有重要意义。研究了43名HIV阳性,抗逆转录病毒疗法的初次参加男性健康诊所的参与者。精液病毒载量和血液病毒载量通常相关,而血液病毒载量> 10,000 cp / ml的个体通常检测到精液病毒载量。但是,我们发现1个人的病毒载量(< 20cp / ml)和2个血液病毒载量极低的个体(97和333cp / ml),但精液中可检测到HIV-1(485-1157份/精液样本)。在过去5年中进行了3次测试后,第一个个体的血液病毒载量无法检测到。我们证实,精液中的HIV-1病毒载量通常与血液病毒载量有关。但是,在少数个体中却并非如此,这表明尽管有其他有效的免疫控制方法,少数个体在男性生殖道中的复制水平却出乎意料地高。这可能反映了当地HIV-1人群的建立。我们证实,精液中的HIV-1病毒载量通常与血液病毒载量有关。尽管如此,在少数个体中却并非如此,这表明尽管有其他有效的免疫控制方法,少数个体在男性生殖道中的复制水平却出乎意料地高。这可能反映了当地HIV-1人群的建立。我们证实,精液中的HIV-1病毒载量通常与血液病毒载量有关。尽管如此,在少数个体中却并非如此,这表明尽管有其他有效的免疫控制方法,少数个体在男性生殖道中的复制水平却出乎意料地高。这可能反映了当地HIV-1人群的建立。
更新日期:2020-04-22
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