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Akkermansia muciniphila protects intestinal mucosa from damage caused by S. pullorum by initiating proliferation of intestinal epithelium.
Veterinary Research ( IF 4.4 ) Pub Date : 2020-03-05 , DOI: 10.1186/s13567-020-00755-3 Linda Zhu 1 , Xiaoxi Lu 1 , Li Liu 2 , Josef Voglmeir 2 , Xiang Zhong 3 , Qinghua Yu 1
Veterinary Research ( IF 4.4 ) Pub Date : 2020-03-05 , DOI: 10.1186/s13567-020-00755-3 Linda Zhu 1 , Xiaoxi Lu 1 , Li Liu 2 , Josef Voglmeir 2 , Xiang Zhong 3 , Qinghua Yu 1
Affiliation
Akkermansia muciniphila, a novel mucin-degrading bacterium, has been demonstrated to prevent the development of obesity and related complications. However, whether it can protect poultry from intestinal mucosal damage by enteropathogens has never been mentioned. In this study, we found that A. muciniphila colonized in the intestine and then relieved intestinal mucosal damage in chicks caused by S. pullorum, including anatomical and morphological damage, alleviation of body weight and intestinal inflammation. The repair process activated by A. muciniphila is accompanied by an increase in the number of goblet cells in the chick’s intestine and an up-regulation of Mucin 2 and trefoil factor 2 (Tff2). In addition, we also demonstrate that A. muciniphila improved colon length, crypt depth, increased the proliferating cell nuclear antigen, with the accelerated proliferation of intestinal epithelium through Wnt/β-catenin signaling pathway, thereby restoring the damaged intestinal mucosa. This study suggests that A. muciniphila activates the proliferation of intestinal cells protecting the intestinal barrier, thus relieving infection with S. pullorum in chickens.
中文翻译:
Akkermansia muciniphila通过启动肠上皮的增殖来保护肠粘膜免受白痢链球菌造成的损害。
Akkermansia muciniphila是一种新型的黏蛋白降解细菌,已被证明可预防肥胖症和相关并发症的发展。但是,它是否能够保护家禽免受肠病原菌引起的肠粘膜损害从未被提及。在这项研究中,我们发现黏液曲霉在肠道中定植,然后缓解了由鸡白痢链球菌引起的鸡肠道粘膜损伤,包括解剖学和形态学损伤,体重减轻和肠道炎症。黏液曲霉激活的修复过程伴随着雏鸡肠道中杯状细胞数量的增加以及粘蛋白2和三叶因子2(Tff2)的上调。此外,我们还证明了A. muciniphila可以改善结肠长度,隐窝深度,增加增殖细胞核抗原,通过Wnt /β-catenin信号通路加速肠上皮的增殖,从而恢复受损的肠粘膜。这项研究表明,黏液曲霉可激活肠道细胞的增殖,从而保护肠道屏障,从而减轻鸡白痢链球菌的感染。
更新日期:2020-04-22
中文翻译:
Akkermansia muciniphila通过启动肠上皮的增殖来保护肠粘膜免受白痢链球菌造成的损害。
Akkermansia muciniphila是一种新型的黏蛋白降解细菌,已被证明可预防肥胖症和相关并发症的发展。但是,它是否能够保护家禽免受肠病原菌引起的肠粘膜损害从未被提及。在这项研究中,我们发现黏液曲霉在肠道中定植,然后缓解了由鸡白痢链球菌引起的鸡肠道粘膜损伤,包括解剖学和形态学损伤,体重减轻和肠道炎症。黏液曲霉激活的修复过程伴随着雏鸡肠道中杯状细胞数量的增加以及粘蛋白2和三叶因子2(Tff2)的上调。此外,我们还证明了A. muciniphila可以改善结肠长度,隐窝深度,增加增殖细胞核抗原,通过Wnt /β-catenin信号通路加速肠上皮的增殖,从而恢复受损的肠粘膜。这项研究表明,黏液曲霉可激活肠道细胞的增殖,从而保护肠道屏障,从而减轻鸡白痢链球菌的感染。