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What is the effectiveness of various invitation methods to a colonoscopy in the early detection and prevention of colorectal cancer? Protocol of a systematic review.
Systematic Reviews ( IF 3.7 ) Pub Date : 2020-03-06 , DOI: 10.1186/s13643-020-01312-x
Undine Antonia Stark 1 , Thomas Frese 1 , Susanne Unverzagt 1, 2 , Alexander Bauer 1
Affiliation  

BACKGROUND Colorectal cancer, a prevalent malignancy worldwide, is associated with numerous modifiable and non-modifiable risk factors that play a role in the early detection and successful treatment of cancer. Despite improvements in the availability and quality of screening methods, especially colonoscopy, and the substantial survival benefits of the early detection of colorectal cancer, patient participation remains low due to clinical reasons and patient barriers. Studies around the world have used various methods of invitation in order to promote patient uptake of colonoscopies. The main objective of this systematic review is to analyze the association between certain invitation procedures, the participation in colonoscopies, and important patient outcomes in the early detection and prevention of colorectal cancer. METHOD We will systematically search in electronic databases including Medline via PubMed and Ovid, Cumulative Index of Nursing and Allied Health Literature (CINAHL), and the Cochrane Library. All studies will be described in a table of study characteristics with a risk of bias assessment. In addition, two authors will independently rate the overall quality of evidence for the critical outcomes using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) Working Group approach. Discrepancies regarding the inclusion of studies, data extraction, or risk of bias assessment will be resolved independently by one other reviewer. Due to the heterogeneous design of the studies that will be evaluated in this review, synthesizing data from these studies in the form of a meta-analysis may not be possible. In this instance, we can conduct a descriptive synthesis of data from these studies. DISCUSSION The results that arise from this systematic review will reflect the influence that various invitation procedures to a colonoscopy have on patient participation in these screenings. Drawing conclusions about the efficiency of various invitation methods to a colonoscopy can provide valuable information to both clinicians and patients and may not only improve future invitation-based patient recruitment to colonoscopy screenings, but also shape guidelines regarding prevention of colorectal cancer. SYSTEMATIC REVIEW REGISTRATION PROSPERO CRD42019128645.

中文翻译:

各种邀请结肠镜检查的方法对于早期发现和预防结直肠癌的效果如何?系统评价协议。

背景技术结直肠癌是世界范围内普遍存在的恶性肿瘤,与许多可改变和不可改变的危险因素相关,这些危险因素在癌症的早期检测和成功治疗中发挥作用。尽管筛查方法(尤其是结肠镜检查)的可用性和质量有所提高,并且结直肠癌的早期检测带来了巨大的生存益处,但由于临床原因和患者障碍,患者参与度仍然较低。世界各地的研究使用了各种邀请方法来促进患者接受结肠镜检查。本系统评价的主要目的是分析某些邀请程序、结肠镜检查的参与以及结直肠癌早期检测和预防中重要的患者结果之间的关联。方法 我们将系统地检索电子数据库,包括通过 PubMed 和 Ovid 提供的 Medline、护理和联合健康文献累积索引 (CINAHL) 以及 Cochrane 图书馆。所有研究都将在研究特征表中进行描述,并进行偏倚风险评估。此外,两位作者将使用建议分级、评估、制定和评价 (GRADE) 工作组方法独立评估关键结果的证据总体质量。有关研究纳入、数据提取或偏倚风险评估的差异将由另一位审稿人独立解决。由于本次综述中将评估的研究的异质性设计,以荟萃分析的形式综合这些研究的数据可能是不可能的。在这种情况下,我们可以对这些研究的数据进行描述性综合。讨论 本次系统评价的结果将反映结肠镜检查的各种邀请程序对患者参与这些筛查的影响。对各种结肠镜检查邀请方法的效率得出结论可以为临床医生和患者提供有价值的信息,不仅可以改善未来基于邀请的患者招募结肠镜检查的情况,还可以形成预防结直肠癌的指南。系统审查注册 PROSPERO CRD42019128645。
更新日期:2020-04-22
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