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Caspase-1 as a regulatory molecule of lipid metabolism.
Lipids in Health and Disease ( IF 4.5 ) Pub Date : 2020-03-06 , DOI: 10.1186/s12944-020-01220-y Meseret Derbew Molla 1 , Birhanu Ayelign 2 , Gashaw Dessie 1 , Zeleke Geto 3 , Tesfahun Dessale Admasu 1
Lipids in Health and Disease ( IF 4.5 ) Pub Date : 2020-03-06 , DOI: 10.1186/s12944-020-01220-y Meseret Derbew Molla 1 , Birhanu Ayelign 2 , Gashaw Dessie 1 , Zeleke Geto 3 , Tesfahun Dessale Admasu 1
Affiliation
Caspase-1 is an evolutionarily conserved inflammatory mediated enzyme that cleaves and activates inflammatory cytokines. It can be activated through the assembly of inflammasome and its major effect is to activate the pro-inflammatory cytokines; interleukin 1β (IL-1β) and interluekine-18 (IL-18). In addition to IL-1β and IL-8, several lines of evidence showed that caspase-1 targets the substrates that are involved in different metabolic pathways, including lipid metabolism. Caspase-1 regulates lipid metabolism through cytokine dependent or cytokine independent regulation of genes that involved in lipid metabolism and its regulation. To date, there are several reports on the role of caspase-1 in lipid metabolism. Therefore, this review is aimed to summarize the role of caspase-1 in lipid metabolism and its regulation.
中文翻译:
Caspase-1作为脂质代谢的调节分子。
Caspase-1是一种进化保守的炎症介导的酶,可裂解并激活炎症细胞因子。它可以通过炎症小体的组装而被激活,其主要作用是激活促炎细胞因子。白介素1β(IL-1β)和白介素18(IL-18)。除IL-1β和IL-8外,几条证据还表明caspase-1可以靶向参与不同代谢途径(包括脂质代谢)的底物。Caspase-1通过细胞因子依赖性或细胞因子非依赖性调节参与脂质代谢及其调控的基因来调节脂质代谢。迄今为止,有几篇关于caspase-1在脂质代谢中的作用的报道。因此,本综述旨在总结caspase-1在脂质代谢及其调控中的作用。
更新日期:2020-04-22
中文翻译:
Caspase-1作为脂质代谢的调节分子。
Caspase-1是一种进化保守的炎症介导的酶,可裂解并激活炎症细胞因子。它可以通过炎症小体的组装而被激活,其主要作用是激活促炎细胞因子。白介素1β(IL-1β)和白介素18(IL-18)。除IL-1β和IL-8外,几条证据还表明caspase-1可以靶向参与不同代谢途径(包括脂质代谢)的底物。Caspase-1通过细胞因子依赖性或细胞因子非依赖性调节参与脂质代谢及其调控的基因来调节脂质代谢。迄今为止,有几篇关于caspase-1在脂质代谢中的作用的报道。因此,本综述旨在总结caspase-1在脂质代谢及其调控中的作用。