Obesity can significantly reduce health-related quality of life (HRQoL) and may lead to numerous health problems even in youths. This study aimed to investigate whether HRQoL varies among youths with obesity depending on grade of obesity and other factors. For the Youths with Extreme obesity Study (YES) (2012–2014), a prospective multicenter cohort study, a baseline sample of 431 obese and extremely obese adolescents and young adults (age 14 to 24 years, BMI ≥30 kg/m2) was recruited at four German university medical centers and one job center. Obesity grade groups (OGG) were defined according to BMI (OGG I: 30–34.9 kg/m2, OGG II: 35–39.9 kg/m2, OGG III (extreme obesity): ≥40 kg/m2). HRQoL was measured with the Euroqol-5D-3 L (EQ-5D-3 L), DISABKIDS chronic generic (DCGM-31) and the KINDLR obesity module. Differences between OGGs were assessed with logistic and linear regression models, adjusting for age, sex, and study center in the base model. In a second regression analysis, we included other characteristics to identify possible determinants of HRQoL. Three hundred fifty-two adolescents (mean age: 16.6 (±2.4), mean BMI: 39.1 (±7.5) kg/ m2) with available HRQoL data were analysed. HRQoL of youths in all OGGs was markedly lower than reference values of non-obese adolescents. Adjusting for age and sex, HRQoL of youths in OGG III significantly impaired compared to OGG I. Youths in OGG III were 2.15 times more likely to report problems with mobility in the EQ-5D-3 L than youths in OGG I. A mean difference of 9.7 and 6.6 points between OGG III and I were found for DCGM-31 and KINDL respectively and 5.1 points between OGG II and I for DCGM-31. Including further variables into the regression models, showed that HRQoL measured by DCGM-31 was significantly different between OGGs. Otherwise, female sex and having more than 4 h of daily screen time were also associated with lower HRQoL measured by DCGM-31 and KINDL. HRQoL of adolescents with obesity is reduced, but HRQoL of adolescents with extreme obesity is particularly affected. Larger and longitudinal studies are necessary to understand the relation of extreme obesity and HRQoL, and the impact of other lifestyle or socioeconomic factors. Clinicaltrials.gov NCT01625325; German Clinical Trials Register (DRKS) DRKS00004172.

中文翻译：

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与青少年极端肥胖相关的健康相关生活质量-是的YES研究的基线评估结果。

肥胖会显着降低与健康有关的生活质量（HRQoL），甚至可能导致青年人出现许多健康问题。这项研究旨在调查肥胖青年中的HRQoL是否根据肥胖等级和其他因素而有所不同。对于前瞻性多中心队列研究（2012-2014年）的青少年，该研究的基线样本为431名肥胖和极度肥胖的青少年和年轻人（14至24岁，BMI≥30 kg / m2）。在四个德国大学医疗中心和一个就业中心招聘。根据BMI定义肥胖等级组（OGG）（OGG I：30-34.9 kg / m2，OGG II：35-39.9 kg / m2，OGG III（极度肥胖）：≥40 kg / m2）。HRQoL使用Euroqol-5D-3 L（EQ-5D-3 L），DISABKIDS慢性仿制药（DCGM-31）和KINDLR肥胖模块进行测量。使用逻辑模型和线性回归模型评估OGG之间的差异，并根据基本模型中的年龄，性别和学习中心进行调整。在第二次回归分析中，我们包括了其他特征，以确定HRQoL的可能决定因素。分析了具有可用HRQoL数据的352名青少年（平均年龄：16.6（±2.4），平均BMI：39.1（±7.5）kg / m2）。所有OGG中青年的HRQoL显着低于非肥胖青少年的参考值。调整年龄和性别后，与OGG I相比，OGG III的年轻人的HRQoL显着降低。OGGIII的年轻人报告EQ-5D-3 L行动不便的可能性是OGG I的年轻人的2.15倍。平均差异对于DCGM-31和KINDL，分别发现OGG III和I之间的9.7和6.6点，对于DCGM-31，发现OGG II和I之间的5.1点。将更多变量包括到回归模型中，表明DCGM-31测量的HRQoL在OGG之间显着不同。否则，女性和每天筛查时间超过4小时也与DCGM-31和KINDL测得的HRQoL降低有关。肥胖青少年的HRQoL降低，但是极端肥胖青少年的HRQoL尤其受影响。为了理解极端肥胖与HRQoL的关系以及其他生活方式或社会经济因素的影响，有必要进行较大规模的纵向研究。Clinicaltrials.gov NCT01625325; 德国临床试验注册（DRKS）DRKS00004172。女性和每天筛查时间超过4小时也与DCGM-31和KINDL测得的HRQoL降低有关。肥胖青少年的HRQoL降低，但是极端肥胖青少年的HRQoL尤其受影响。为了理解极端肥胖与HRQoL的关系以及其他生活方式或社会经济因素的影响，有必要进行较大规模的纵向研究。Clinicaltrials.gov NCT01625325; 德国临床试验注册（DRKS）DRKS00004172。女性和每天筛查时间超过4小时也与DCGM-31和KINDL测得的HRQoL降低有关。肥胖青少年的HRQoL降低，但是极端肥胖青少年的HRQoL尤其受影响。为了理解极端肥胖与HRQoL的关系以及其他生活方式或社会经济因素的影响，有必要进行较大规模的纵向研究。Clinicaltrials.gov NCT01625325; 德国临床试验注册（DRKS）DRKS00004172。