There remains a lack of large-scale clinical studies of cognitive impairment that aim to increase diagnostic and prognostic accuracy as well as validate previous research findings. The MemClin project will amass large quantities of cross-disciplinary data allowing for the construction of robust models to improve diagnostic accuracy, expand our knowledge on differential diagnostics, strengthen longitudinal prognosis, and harmonise examination protocols across centres. The current article describes the Memory Clinic (MemClin) project’s study-design, materials and methods, and patient characteristics. In addition, we present preliminary descriptive data from the ongoing data collection. Nine out of ten memory clinics in the greater Stockholm area, which largely use the same examination methods, are included. The data collection of patients with different stages of cognitive impairment and dementia is coordinated centrally allowing for efficient and secure large-scale database construction. The MemClin project rest directly on the memory clinics examinations with cognitive measures, health parameters, and biomarkers. Currently, the MemClin project has informed consent from 1543 patients. Herein, we present preliminary data from 835 patients with confirmed cognitive diagnosis and neuropsychological test data available. Of those, 239 had dementia, 487 mild cognitive impairment (MCI), and 104 subjective cognitive impairment (SCI). In addition, we present descriptive data on visual ratings of brain atrophy and cerebrospinal fluid markers. Based on our current progress and preliminary data, the MemClin project has a high potential to provide a large-scale database of 1200–1500 new patients annually. This coordinated data collection will allow for the construction of improved diagnostic and prognostic models for neurodegenerative disorders and other cognitive conditions in their naturalistic setting.

中文翻译：

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MemClin项目：针对认知障碍早期阶段的前瞻性多记忆诊所研究

缺乏针对认知障碍的大规模临床研究，旨在提高诊断和预后的准确性以及验证先前的研究结果。MemClin项目将收集大量的跨学科数据，以构建健壮的模型来提高诊断准确性，扩大我们对差异诊断的知识，加强纵向预后并协调各个中心的检查规程。当前的文章描述了记忆诊所（MemClin）项目的研究设计，材料和方法以及患者特征。此外，我们提供了正在进行的数据收集中的初步描述性数据。在大斯德哥尔摩地区，十分之九的记忆诊所中，有九个主要使用相同的检查方法。集中协调患有认知障碍和痴呆症不同阶段的患者的数据收集，从而实现高效，安全的大规模数据库建设。MemClin项目直接依靠记忆诊所的检查，包括认知措施，健康参数和生物标记物。目前，MemClin项目已获得1543位患者的知情同意。在本文中，我们提供了来自835名患者的初步数据，这些患者已证实了认知诊断和神经心理学测试数据。在这些人中，有239人患有痴呆症，487例轻度认知障碍（MCI）和104例主观认知障碍（SCI）。此外，我们介绍了脑萎缩和脑脊髓液标记物的视觉评级的描述性数据。根据我们目前的进展和初步数据，MemClin项目具有很大的潜力，每年可提供1200至1500名新患者的大规模数据库。这种协调的数据收集将允许在自然状态下针对神经退行性疾病和其他认知状况构建改进的诊断和预后模型。