Molecular profiling of DNA and RNA has provided valuable new insights into the genetic basis of non-malignant and malignant disorders, as well as an increased understanding of basic mechanisms that regulate human disease. Recent technological advances have enabled the analyses of alterations in gene-based structure or function in a comprehensive, high-throughput fashion showing that each tumor type typically exhibits distinct constellations of genetic alterations targeting one or more key cellular pathways that regulate cell growth and proliferation, evasion of the immune system, and other aspects of cancer behavior. These advances have important implications for future research and clinical practice in areas as molecular diagnostics, the implementation of gene or pathway-directed targeted therapy, and the use of such information to drive drug discovery. The 1st international and 32nd Annual Conference of Italian Association of Cell Cultures (AICC) conference wanted to offer the opportunity to match technological solutions and clinical needs in the era of precision medicine.

中文翻译：

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从单基因分析到单细胞分析：精密医学的新时代

DNA和RNA的分子概况分析为非恶性和恶性疾病的遗传基础提供了有价值的新见解，并且对调节人类疾病的基本机制的理解也不断增强。最近的技术进步已使以全面，高通量的方式分析基于基因的结构或功能发生的变化，表明每种肿瘤类型通常表现出针对一种或多种调节细胞生长和增殖的关键细胞途径的遗传改变的不同构象，逃避免疫系统以及癌症行为的其他方面。这些进展对于分子诊断，基因或通路导向的靶向治疗，以及使用此类信息来推动药物发现。意大利细胞培养协会（AICC）会议的第1届国际会议和第32届年会希望提供机会，以匹配精确医学时代的技术解决方案和临床需求。