To understand diversity in enormous collections of genome sequences, we need computationally scalable tools that can quickly contextualize individual genomes based on their similarities and identify features of each genome that make them unique. We present WhatsGNU, a tool based on exact match proteomic compression that, in seconds, classifies any new genome and provides a detailed report of protein alleles that may have novel functional differences. We use this technique to characterize the total allelic diversity (panallelome) of Salmonella enterica , Mycobacterium tuberculosis , Pseudomonas aeruginosa, and Staphylococcus aureus . It could be extended to others. WhatsGNU is available from https://github.com/ahmedmagds/WhatsGNU .

中文翻译：

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WhatsGNU：识别蛋白质组学新颖性的工具

为了理解庞大的基因组序列集合中的多样性，我们需要计算可扩展的工具，这些工具可以根据它们的相似性快速地将单个基因组置于上下文中，并识别每个基因组的特征，使其独一无二。我们展示了 WhatsGNU，这是一种基于精确匹配蛋白质组学压缩的工具，可在几秒钟内对任何新基因组进行分类，并提供可能具有新功能差异的蛋白质等位基因的详细报告。我们使用这种技术来表征肠道沙门氏菌、结核分枝杆菌、铜绿假单胞菌和金黄色葡萄球菌的总等位基因多样性（泛基因组）。它可以扩展到其他人。WhatsGNU 可从 https://github.com/ahmedmagds/WhatsGNU 获得。