The preparation of millimeter‐sized poly(acrylamide‐co‐acrylic acid) hydrogel beads via inverse Pickering emulsion polymerization using starch‐based nanoparticles (SNPs) as stabilizers is reported. Amphiphilic starch is fabricated by the introduction of butyl glycidyl ether groups and palmitate groups, and the hydrophobically modified SNPs are fabricated by a nanoprecipitation process. The obtained SNPs could adsorb at oil‐water interfaces to stabilize an inverse Pickering emulsion, and the effects of oil/water volume fraction ratio and SNP concentration on emulsions are comprehensively studied. Poly(acrylamide‐co‐acrylic acid) hydrogel beads with a size of approximately 1 mm are obtained by inverse Pickering emulsion polymerization stabilized by SNPs. The morphology and structure of hydrogel beads are extensively investigated, which confirms that SNPs locate on the surface of hydrogel beads and act as emulsifiers and network structures present inside the beads. Polymerization is also detected to investigate the potential formation mechanism of hydrogel beads. The pH‐responsive property of hydrogel beads and its potential application for drug delivery are also explored.

中文翻译：

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以淀粉基纳米粒子为乳化剂通过逆式Pickering聚合合成毫米级水凝胶珠

据报道，使用基于淀粉的纳米颗粒（SNP）作为稳定剂，通过反向Pickering乳液聚合制备了毫米大小的聚（丙烯酰胺-丙烯酸）水凝胶珠。通过引入丁基缩水甘油醚基团和棕榈酸酯基团来制备两亲性淀粉，并且通过纳米沉淀法来制备疏水改性的SNP。所获得的单核苷酸多态性可以吸附在油水界面上，以稳定反Pickering乳液，并综合研究了油水体积分数比和SNP浓度对乳液的影响。通过SNPs稳定的反相Pickering乳液聚合可制得大小约为1 mm的聚（丙烯酰胺-丙烯酸）水凝胶珠。水凝胶珠的形态和结构已被广泛研究，这证实了SNP位于水凝胶微珠的表面，并充当微珠内部的乳化剂和网络结构。还检测到聚合反应以研究水凝胶珠的潜在形成机理。还探讨了水凝胶珠的pH响应特性及其在药物递送中的潜在应用。