Development of reliable, sensitive, selective, and miniaturized sensing technologies is critical for health assessment and early diagnosis and treatment of diseases/anomalies while simultaneously mitigating the challenges associated with in vivo measurements. Some critical constraints to the realization of in vivo measurements include the necessity to fabricate the sensor on a tightly constrained footprint while ensuring acceptable biocompatibility, accuracy, and reliability. The inherent light‐guiding properties of optical fibers over long distances, their microscopic cross‐section that can be structured at the nanoscale to manipulate the light transmittance/reflectance spectrum, excellent biocompatibility enabling their efficient integration with biorecognition molecules, immunity to electromagnetic interference, mechanical flexibility, and low cost have been inviting research attention to utilize these unique features for in vivo and label‐free point‐of‐care diagnostics. Hence, fiber‐optic biosensing has become a promising research thrust, with a plethora of emerging methodologies to develop ultrasensitive and selective sensing probes. A unified presentation of the research trends on biosensors incorporated into optical fibers is presented.

中文翻译：

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用于现场诊断和体内生物传感的光纤技术的进展

开发可靠，灵敏，选择性和小型化的传感技术对于健康评估以及疾病/异常的早期诊断和治疗，同时缓解与体内测量相关的挑战至关重要。实现体内测量的一些关键约束条件包括必须在严格限制的占地面积上制造传感器，同时确保可接受的生物相容性，准确性和可靠性。长距离光纤的固有导光特性，可以在纳米级构造的微观截面以控制光透射/反射光谱，出色的生物相容性使其能够与生物识别分子有效整合，抗电磁干扰，机械灵活性，低成本和低成本一直吸引研究关注，以将这些独特功能用于体内和无标签即时诊断。因此，光纤生物传感已成为一种有前途的研究方向，它具有大量新兴方法来开发超灵敏和选择性传感探头。提出了对结合到光纤中的生物传感器的研究趋势的统一介绍。