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Clickable iron oxide NPs based on catechol derived ligands: synthesis and characterization
Soft Matter ( IF 3.4 ) Pub Date : 2020/03/05 , DOI: 10.1039/c9sm02512j Esther Pozo-Torres 1 , Carlos Caro 1, 2 , Ashish Avasthi 2 , Jose María Páez-Muñoz 2 , María Luisa García-Martín 2, 3 , Inmaculada Fernández 1 , Manuel Pernia Leal 1
Soft Matter ( IF 3.4 ) Pub Date : 2020/03/05 , DOI: 10.1039/c9sm02512j Esther Pozo-Torres 1 , Carlos Caro 1, 2 , Ashish Avasthi 2 , Jose María Páez-Muñoz 2 , María Luisa García-Martín 2, 3 , Inmaculada Fernández 1 , Manuel Pernia Leal 1
Affiliation
Clickable magnetic nanoparticles have attracted great attention as potential nanoplatforms for biomedical applications because of the high functionalization efficiency of their surfaces with biomolecules, which facilitates their bio-compatibilization. However, the design and synthesis of clickable NPs is still challenging because of the complexity of the chemistry on the magnetic NP surface, thus robust methods that improve the ligand synthesis and the transfer of magnetic NPs in physiological media being in high-demand. In this work, we developed a versatile and enhanced synthetic route to fabricate potentially clickable IONPs of interest in nanomedicine. Catechol anchor ligands with different stereo-electronic features were synthetized from a hetero bi-functional PEG spacer backbone. The resulting catechol ligands transferred in good yields and high stability to magnetic NPs by an improved energetic ligand exchange method that combines sonication and high temperature. The azido functionalized IONPs exhibited excellent characteristics as T2 MRI contrast agents with low cytotoxicity, making these clickable magnetic NPs promising precursors for nanomedicines.
中文翻译:
基于邻苯二酚衍生配体的可点击氧化铁纳米颗粒:合成和表征
可点击的磁性纳米粒子作为生物医学应用的潜在纳米平台引起了极大的关注,因为它们的表面具有生物分子的高功能化效率,这有利于它们的生物相容性。然而,由于磁性纳米颗粒表面化学的复杂性,可点击纳米颗粒的设计和合成仍然具有挑战性,因此对改善配体合成和磁性纳米颗粒在生理介质中转移的稳健方法有很高的需求。在这项工作中,我们开发了一种多功能且增强的合成路线来制造纳米医学中感兴趣的潜在可点击 IONP。具有不同立体电子特征的儿茶酚锚配体由异质双功能 PEG 间隔骨架合成。通过结合超声处理和高温的改进的能量配体交换方法,所得儿茶酚配体以良好的产率和高稳定性转移到磁性纳米颗粒上。叠氮基功能化的 IONPs 表现出优异的特性,如T 2 MRI 造影剂具有低细胞毒性,使这些可点击的磁性 NPs 成为纳米药物的有前途的前体。
更新日期:2020-04-01
中文翻译:
基于邻苯二酚衍生配体的可点击氧化铁纳米颗粒:合成和表征
可点击的磁性纳米粒子作为生物医学应用的潜在纳米平台引起了极大的关注,因为它们的表面具有生物分子的高功能化效率,这有利于它们的生物相容性。然而,由于磁性纳米颗粒表面化学的复杂性,可点击纳米颗粒的设计和合成仍然具有挑战性,因此对改善配体合成和磁性纳米颗粒在生理介质中转移的稳健方法有很高的需求。在这项工作中,我们开发了一种多功能且增强的合成路线来制造纳米医学中感兴趣的潜在可点击 IONP。具有不同立体电子特征的儿茶酚锚配体由异质双功能 PEG 间隔骨架合成。通过结合超声处理和高温的改进的能量配体交换方法,所得儿茶酚配体以良好的产率和高稳定性转移到磁性纳米颗粒上。叠氮基功能化的 IONPs 表现出优异的特性,如T 2 MRI 造影剂具有低细胞毒性,使这些可点击的磁性 NPs 成为纳米药物的有前途的前体。