Concise synthesis of α-amino cyclic boronates via multicomponent coupling of salicylaldehydes, amines, and B2(OH)4,Green Chemistry

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Concise synthesis of α-amino cyclic boronates via multicomponent coupling of salicylaldehydes, amines, and B2(OH)4
Green Chemistry ( IF 9.8 ) Pub Date : 2020-03-05 , DOI: 10.1039/d0gc00346h
Wenbo Ming _{1,

2,

3,

4} , Xiaocui Liu _{1,

2,

3,

4} , Alexandra Friedrich _{1,

2,

3,

4} , Johannes Krebs _{1,

2,

3,

4} , Yudha P. Budiman _{1,

2,

3,

4,

5} , Mingming Huang _{1,

2,

3,

4} , Todd B. Marder _{1,

2,

3,

4}

Affiliation

We report here a concise synthesis of α-amino cyclic boronates via multicomponent coupling of readily available salicylaldehydes, amines, and B₂(OH)₄. The process can be carried out at room temperature in ethanol, does not require catalysts or additives, and is easy to scale up. Aminals and ligated boroxines are intermediates in this reaction.

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