Investigating potential gray matter differences in adolescents presenting higher levels of schizotypy personality traits could bring further insights into the development of schizophrenia spectrum disorders. Research has yet to examine the morphological correlates of schizotypy features during adolescence prospectively, and no information is available on the developmental trajectories from adolescence to adulthood. We employed mixed model regression analysis to investigate developmental trajectories of cortical thickness (CT) in relation to schizotypy dimensions in a cohort of 109 adolescents from the general population for whom MRI-scans were acquired over a 5-year period, culminating in a total of 271 scans. Structural data were processed with FreeSurfer software, statistical analyses were conducted using mixed regression models following a ROI-based approach, and schizotypy was assessed with the Schizotypal Personality Questionnaire (SPQ). Accelerated thinning was observed in the posterior cingulate cortex in relation to high levels of positive schizotypy, whereas high levels of disorganized schizotypy were associated with a similar trajectory pattern in the anterior cingulate cortex. The developmental course of CT in the prefrontal, occipital, and cingulate cortices differed between adolescents expressing higher vs lower levels of negative schizotypy. Participants reporting high scores on all schizotypy dimensions were associated with differential trajectories of CT in posterior cingulate cortex and occipital cortex. Consistently with prospective developmental studies of clinical risk conversion, the negative schizotypy dimension appears to constitute the most informative dimension for psychosis-related psychopathology, as its cerebral correlates in adolescents most closely overlap with results found in clinical high risk for psychosis studies.

中文翻译：

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青春期皮层厚度与精神分裂症的发展轨迹。

研究表现出较高水平的精神分裂型人格特质的青少年潜在的灰质差异，可以为精神分裂症谱系障碍的发展带来更多的见解。尚无研究前瞻性地检查青春期期间精神分裂症特征的形态相关性，并且尚无关于从青春期到成年期的发展轨迹的信息。我们采用混合模型回归分析研究了在5年内获得MRI扫描的109名青少年人群中皮层厚度（CT）与精神分裂症尺寸相关的发展轨迹。 271次扫描。结构数据使用FreeSurfer软件处理，使用基于ROI的方法，使用混合回归模型进行统计分析，并通过精神分裂症人格问卷（SPQ）评估精神分裂症。与高水平的阳性精神分裂症有关，在后扣带回皮层中观察到加速变薄，而高水平的混乱的精神分裂症与前扣带回皮质中相似的轨迹模式相关。在表现出较高和较低水平的阴性精神分裂症的青少年之间，前额叶，枕叶和扣带回皮质CT的发育过程有所不同。参加者在所有精神分裂症维度上均获得高分，与后扣带回皮层和枕叶皮层CT的不同轨迹相关。与临床风险转换的前瞻性研究一致，