Objective

To examine associations between in utero marijuana exposure and birth outcomes.

Study design

In two separate cohorts (Appalachian, Rocky Mountain), data were collected from medical records. Marijuana exposure was positive based on urine drug screening at delivery, with nonexposed controls matched on multiple factors including other substance exposure.

Result

Marijuana-exposed newborns (n = 531) had significantly worse birth outcomes than controls (n = 531), weighing 218 g less, 82%, 79%, and 43% more likely to be low birth weight, preterm, or admitted to the NICU, respectively, and significantly lower Apgar scores.

Conclusion

Marijuana exposure in utero predicted newborn factors linked to longer-term health and development issues. Effects were not attributable to other comorbidities in this study due to rigorous matching and biochemical verification of marijuana and other drug use. Findings add to growing evidence linking marijuana exposure to adverse birth and longer-term outcomes. Women should be encouraged to avoid marijuana use during pregnancy.

中文翻译：

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怀孕大麻使用对出生结果的影响：来自两个匹配的基于人群的队列的结果。

客观的

检查子宫内大麻暴露与出生结果之间的关联。

学习规划

在两个独立的队列（阿巴拉契亚山脉、落基山）中，数据是从医疗记录中收集的。根据分娩时的尿液药物筛查，大麻暴露呈阳性，未暴露的对照与包括其他物质暴露在内的多种因素相匹配。

结果

接触大麻的新生儿 ( n  = 531) 的出生结果明显比对照组 ( n  = 531) 差，体重减轻 218 克，低出生体重、早产或入院的可能性分别高出82%、79% 和 43%。 NICU 和显着降低 Apgar 评分。

结论

子宫内接触大麻可预测与长期健康和发育问题相关的新生儿因素。由于大麻和其他药物使用的严格匹配和生化验证，影响不能归因于本研究中的其他合并症。研究结果增加了越来越多的证据，将大麻暴露与不良生育和长期结果联系起来。应鼓励妇女在怀孕期间避免使用大麻。