Supramolecular organizing center (SMOC)-mediated signal transduction is an emerging concept in the field of signal transduction that is ushering in a new era. The formation of location-specific, higher-order SMOCs is particularly important for cell death and innate immune signaling processes. Several protein interaction domains, including the death domain (DD) superfamily and the CIDE domain, are representative mediators of SMOC assembly in cell death and innate immune signaling pathways. DD superfamily- and CIDE domain-containing proteins form SMOCs that activate various caspases and provide signaling scaffold platforms. These assemblies can lead to signal transduction and amplification during signaling events. In this review, we summarize recent findings on the molecular basis of DD superfamily- and CIDE domain-mediated SMOC formation.

中文翻译：

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新时代信号转导平台的组装：二聚化，螺旋灯丝组装等。

超分子组织中心（SMOC）介导的信号转导是信号转导领域中的一个新兴概念，正在迎来一个新时代。位置特异性，高阶SMOC的形成对于细胞死亡和先天免疫信号传导过程特别重要。几个蛋白质相互作用域，包括死亡域（DD）超家族和CIDE域，是SMOC组装在细胞死亡和先天免疫信号通路中的代表性介体。包含DD超家族和CIDE结构域的蛋白质形成SMOC，这些SMOC激活各种胱天蛋白酶并提供信号传导平台。这些组件可以在信号事件期间导致信号转导和放大。在这篇综述中，我们总结了DD超家族和CIDE域介导的SMOC形成的分子基础上的最新发现。