Prostate cancer is a common malignancy, but only some tumors are lethal. Accurately identifying these tumors will improve clinical practice and instruct research. Aggressive cancers often have distinctive pathologies, including intraductal carcinoma of the prostate (IDC-P) and ductal adenocarcinoma. Here, we review the importance of these pathologies because they are often overlooked, especially in genomics and preclinical testing. Pathology, genomics, and patient-derived models show that IDC-P and ductal adenocarcinoma accompany multiple markers of poor prognosis. Consequently, “knowing what is growing” will help translate preclinical research to pinpoint and treat high-risk prostate cancer in the clinic.

前列腺癌是一种常见的恶性肿瘤，但只有一些肿瘤是致命的。准确识别这些肿瘤将改善临床实践并指导研究。侵略性癌症通常具有独特的病理学，包括前列腺导管内癌（IDC-P）和导管腺癌。在这里，我们回顾了这些病理的重要性，因为它们常常被忽略，尤其是在基因组学和临床前测试中。病理，基因组学和患者来源的模型表明，IDC-P和导管腺癌伴随着不良预后的多个标志。因此，“了解正在增长的东西”将有助于将临床前研究转化为在临床中查明和治疗高危前列腺癌。