Background

Few effective treatments are available for male pattern hair loss (MPHL) or, especially, for female pattern hair loss (FPHL). Recently, cell-based therapies using autologous or allogeneic cells have been used clinically.

Objective

We examined the safety and efficacy of autologous cell–based therapy using dermal sheath cup (DSC) cells to treat MPHL and FPHL.

Methods

DSCs dissected from occipital hair follicles were cultured to manufacture DSC cells. Participants with MPHL or FPHL received single injections of 7.5 × 10⁶, 1.5 × 10⁶, or 3.0 × 10⁵ DSC cells or a placebo in 4 randomized separate regions on the scalp, and hair densities and diameters were measured for 3, 6, 9, and 12 months.

Results

Fifty men and 15 women aged 33 to 64 years were injected with DSC cells. Total hair density and cumulative hair diameter at the 3.0 × 10⁵ DSC cells injection site was significantly increased compared with the placebo after 6 and 9 months. Men and women showed similar improvements, and there were no serious adverse events.

Limitations

No lower cell numbers were tested, and the positive effect was temporary until 9 months.

Conclusion

The results suggest that cell therapy with autologous DSC cells may be useful as a new therapeutic method for treating MPHL and FPHL.

中文翻译：

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使用真皮鞘杯细胞自体基于细胞的男性和女性模式脱发治疗：一项随机安慰剂对照的双盲剂量寻找临床研究。

背景

对于男性型脱发（MPHL），尤其是女性型脱发（FPHL），几乎没有有效的治疗方法。最近，临床上已使用使用自体或同种异体细胞的基于细胞的疗法。

目的

我们检查了使用真皮鞘杯（DSC）细胞治疗MPHL和FPHL的基于自体细胞的疗法的安全性和有效性。

方法

培养从枕毛囊切开的DSC，以制造DSC细胞。与MPHL或FPHL参与者接收到的单次注射7.5×10 ⁶，1.5×10 ⁶，或3.0×10 ⁵ DSC细胞或在4安慰剂随机头皮上的分离的区域，并测定为3,6头发密度和直径， 9、12个月。

结果

分别对五十名男性和15名年龄在33至64岁之间的女性注射了DSC细胞。在6和9个月后，与安慰剂相比，在3.0×10 ⁵ DSC细胞注射部位的总头发密度和累积头发直径明显增加。男性和女性表现出相似的改善，并且没有严重的不良事件。

局限性

没有测试更低的细胞数，并且阳性作用是暂时的，直到9个月。

结论

结果表明，自体DSC细胞的细胞疗法可能作为治疗MPHL和FPHL的新疗法有用。