There is limited understanding of adverse health effect associations with chemical constituents of fine particulate matter (PM2.5) as well as the underlying mechanisms. We outlined a workflow to assess metrics, beyond concentration, using household and personal PM2.5 filter samples collected in India as a proof of concept for future large-scale studies. Oxidative potential, chemical composition (polycyclic aromatic hydrocarbons and elements), and bioactivity (developmental exposures in zebrafish) were determined. Significant differences were observed in all metrics between personal and household PM2.5 samples. This work established methods to characterize multiple metrics of PM2.5 to ultimately support the identification of more health-relevant metrics than concentration.

中文翻译：

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用于比较过滤器收集的 PM2.5 的化学和生物指标的工作流程

对与细颗粒物 (PM2.5) 的化学成分及其潜在机制的不利健康影响关联的了解有限。我们概述了一个工作流程，使用在印度收集的家庭和个人 PM2.5 过滤器样本作为未来大规模研究的概念证明，以评估除浓度之外的指标。确定了氧化潜力、化学成分（多环芳烃和元素）和生物活性（斑马鱼的发育暴露）。在个人和家庭 PM2.5 样本之间的所有指标中都观察到显着差异。这项工作建立了表征 PM2.5 多个指标的方法，以最终支持识别比浓度更与健康相关的指标。