Okazaki and colleagues report that PD-1 signaling mainly restrains effector function at the early stage of T cell activation. The authors find that cytokine genes require strong antigen stimulation and are more susceptible to PD-1 inhibition.

中文翻译：

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PD-1：T细胞衰竭的驾驶员还是乘客？

Okazaki及其同事报告说，PD-1信号传导主要在T细胞活化的早期抑制效应子功能。作者发现，细胞因子基因需要强烈的抗原刺激，并且更容易受到PD-1抑制。