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CRISPR Shields: Fending Off Diverse Cas Nucleases with Nucleus-like Structures.
Molecular Cell ( IF 16.0 ) Pub Date : 2020-03-05 , DOI: 10.1016/j.molcel.2020.02.015
Rodolphe Barrangou 1 , Erik J Sontheimer 2
Affiliation  

Two recent studies have uncovered a novel means by which bacteriophages thwart host immunity. Mendoza et al. (2020) and Malone et al. (2020) demonstrate that a nucleus-like proteinaceous structure shields phage DNA from CRISPR-associated nucleases encompassing Cascade-Cas3, Cas9, and Cas12.



中文翻译:

CRISPR 护盾:抵御具有类核结构的多种 Cas 核酸酶。

最近的两项研究发现了噬菌体阻碍宿主免疫的新方法。门多萨等。(2020) 和马龙等人。(2020) 表明,类核蛋白质结构可保护噬菌体 DNA 免受 CRISPR 相关核酸酶(包括级联-Cas3、Cas9 和 Cas12)的影响。

更新日期:2020-03-05
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