The ability of Bombyx mori Thai silk fibroin (SF) to stimulate IL-10 production from peripheral blood mononuclear cells (PBMCs) derived from healthy and atopic subjects was investigated. We evaluated a safety profile and anti-inflammatory properties of Thai SF, compared to two commercially available biomaterials for wound care and implant, Gelfoam® and Ologen®, by incubating them with PBMCs before determining cell viability and cytokine expression. The results demonstrated that Thai SF was neither toxic to PBMCs nor induces the release of inflammatory cytokines (Th1/Th17-related cytokines and Th2-related cytokines). Interestingly, Thai SF, but not other biomaterials, could stimulate IL-10 production from PBMCs harvested from both healthy individuals and atopic subjects. As IL-10 has an anti-inflammatory and scar preventive properties, our findings indicate that Thai SF is a promising biomaterial for wound dressing in both healthy individuals and in patients who are prone to develop allergic reactions.

家蚕的能力研究了泰国丝素蛋白（SF）刺激来自健康人和特应性受试者的外周血单核细胞（PBMC）产生IL-10的情况。通过在确定细胞活力和细胞因子表达之前，将它们与PBMC孵育，我们评估了泰国SF的安全性和抗炎特性，与两种用于伤口护理和植入物的商用生物材料Gelfoam®和Ologen®进行了比较。结果表明Thai SF既不对PBMC毒性也不诱导炎性细胞因子（Th1 / Th17相关的细胞因子和Th2相关的细胞因子）的释放。有趣的是，泰国的SF，但不是其他生物材料，可以刺激从健康人和特应性受试者收获的PBMC中产生IL-10。由于IL-10具有抗炎和预防疤痕的特性，