Type B trichothecene mycotoxins comprise deoxynivalenol (“Vomitoxin”, DON) and four structually related congeners: 15-acetyl- and 3-acetyl-deoxynivalenol (15-ADON and 3-ADON), nivalenol (NIV), 4-acetyl-nivalenol (fusarenon X, FX). These foodborne mycotoxins has been linked to food poisoning leading to anorexic response in human and several animal species. However, the pathophysiological basis for anorexic effect is relatively unclear. The goal of this research was to compare anorexic effect to type B trichothecenes and relate these effects to two common cytokines tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) following oral and IP exposure. Both cytokines were increased within 1−2 h in plasma and returned to basal concentrations at 6 h following exposure to DON and ADONs. FX evoked both cytokines with initial time and duration at 1−2 h and > 6 h, respectively. Elevation of TNF-α and IL-1β induced by orally exposure to NIV did not occur until 2 h and recovered to basal concentrations at 6 h. Both cytokines were elevated at 1 h and lasted more than 6 h following IP exposure to NIV. Type B trichothecenes stimulated plasma secretion of both cytokines that were consistent with reduction of food intake. In conclusion, our findings demonstrate that TNF-α and IL-1β act critical roles in type B trichothecenes-induced anorexic response.

B型单端孢霉菌真菌毒素包含脱氧雪腐烯酚（“呕吐毒素”，DON）和四个结构上相关的同类物：15-乙酰基和3-乙酰基脱氧雪茄烯醇（15-ADON和3-ADON），新雪茄醇（NIV），4-乙酰基雪茄烯酚（ fusarenon X，FX）。这些食源性霉菌毒素与食物中毒有关，导致人类和几种动物的厌食反应。然而，厌食症的病理生理基础相对不清楚。这项研究的目的是比较口服和IP暴露对B型毛癣菌病的厌食作用，并将这些作用与两种常见的细胞因子肿瘤坏死因子-α（TNF-α）和白细胞介素-1β（IL-1β）相关。两种细胞因子均在血浆中1-2小时内增加，并在暴露于DON和ADON后6小时恢复至基础浓度。FX分别在1-2小时和> 6小时时诱发两种细胞因子的初始时间和持续时间。口服暴露于NIV诱导的TNF-α和IL-1β升高直到2 h才出现，并在6 h恢复至基础浓度。IP暴露于NIV后，两种细胞因子均在1小时升高，并持续超过6小时。B型毛发纤毛虫刺激两种细胞因子的血浆分泌，这与减少食物摄入量是一致的。总之，我们的发现表明，TNF-α和IL-1β在B型毛发纤毛虫引起的厌食反应中起关键作用。B型毛发纤毛虫刺激两种细胞因子的血浆分泌，这与减少食物摄入量是一致的。总之，我们的发现表明，TNF-α和IL-1β在B型毛发纤毛虫引起的厌食反应中起关键作用。B型毛发纤毛虫刺激两种细胞因子的血浆分泌，这与减少食物摄入量是一致的。总之，我们的发现表明，TNF-α和IL-1β在B型毛发纤毛虫引起的厌食反应中起关键作用。