In a study of young adults chosen as unrelated hematopoietic stem cell donors for patients with hematological malignancies, leukemia-associated mutations were detectable in cells from 44% of donors. Donor-origin mutant clones engrafted in recipients and expanded during the first 100 days after transplant, but donor-derived leukemia was not observed.

中文翻译：

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年轻人和躁动不安：移植后供体来源的突变型HSC的扩增。

在一项针对血液恶性肿瘤患者被选为无关造血干细胞供体的年轻人的研究中，在44％的供体细胞中可检测到白血病相关的突变。供体来源的突变体克隆移植到受体中，并在移植后的前100天内扩增，但未观察到供体来源的白血病。