Protein dynamics is undoubtedly a pervasive ingredient in all biological functions. However, structural biology has been strongly driven by a static-centered view of protein architecture. We argue that the recent advances of cryo-electron microscopy (EM) have the potential to more broadly explore the conformational landscapes of protein complexes and therefore will enhance our ability to predict the diverse conformations of tertiary and quaternary protein structures that are functionally relevant in physiological conditions.

中文翻译：

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低温电子显微镜会改变蛋白质结构预测中的当前范例吗？

蛋白质动力学无疑是所有生物学功能中普遍存在的成分。但是，结构生物学受到蛋白质结构静态中心观点的强烈驱动。我们认为，冷冻电子显微镜（EM）的最新进展有可能更广泛地探索蛋白质复合物的构象态势，因此将增强我们预测与生理功能相关的三级和四级蛋白质结构多样化构象的能力。条件。