Dermatologists face difficult questions about the safety of topical and systemic medications during pregnancy and lactation. Safety data regarding these medications can be limited to case studies, animal models, or small cohort studies that lack statistical power. Given the ethical complexities of pregnancy, randomized clinical trials evaluating the use of potentially teratogenic medications are often unfeasible; thus, large cohort studies are typically needed to inform practice.

中文翻译：

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口服和局部用特比萘芬治疗妊娠期真菌感染。

皮肤科医生面临有关妊娠和哺乳期间局部和全身药物安全性的难题。有关这些药物的安全性数据可能仅限于个案研究，动物模型或缺乏统计能力的小型队列研究。考虑到怀孕的伦理复杂性，评估可能使用致畸药物的随机临床试验通常是不可行的。因此，通常需要进行大量的队列研究来指导实践。