Simple febrile convulsion (SFC) is a common disease that is mainly caused by fever from extracranial infections. In this study, we used proteomic approaches involving discovery and validation cohorts to examine the proteomes of serum from children who were diagnosed with SFC, children with fever but without convulsion, and healthy children (normal controls). We identified 86 proteins involved in different biological pathways that were significantly different between the SFC and normal control groups. Of these 86 proteins, 35 had higher expression in the SFC group compared with the normal control group, whereas 51 had lower expression. Notably, fibrinogen-related proteins involved in the coagulation system pathway were markedly decreased in the SFC group. Targeted and absolute quantification of fibrinogen-related proteins was performed and validated the potential of these proteins as biomarkers. Thus, fibrinogen-related proteins may participate in the pathophysiological process of SFC and may be potential biomarkers for the diagnosis of SFC.

中文翻译：

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定量蛋白质组学研究表明，纤维蛋白原相关蛋白可能参与简单的高热惊厥的病理生理过程。

单纯性高热惊厥（SFC）是一种常见疾病，主要由颅外感染引起的发烧引起。在这项研究中，我们使用了涉及发现和验证队列的蛋白质组学方法，检查了被诊断患有SFC的儿童，发烧但无惊厥的儿童和健康儿童（正常对照）的血清蛋白质组。我们鉴定了8​​6种参与不同生物途径的蛋白质，这些蛋白质在SFC和正常对照组之间有显着差异。在这86种蛋白质中，与正常对照组相比，SFC组中有35种蛋白质表达较高，而51种蛋白质则较低。值得注意的是，SFC组中参与凝血系统途径的纤维蛋白原相关蛋白显着减少。进行了与纤维蛋白原相关蛋白的靶向和绝对定量，并验证了这些蛋白作为生物标记物的潜力。因此，纤维蛋白原相关蛋白可能参与SFC的病理生理过程，并且可能是诊断SFC的潜在生物标记。