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Identification and Confirmation of Fentanyls on Paper using Portable Surface Enhanced Raman Spectroscopy and Paper Spray Ionization Mass Spectrometry.
Journal of the American Society for Mass Spectrometry ( IF 3.2 ) Pub Date : 2020-02-18 , DOI: 10.1021/jasms.0c00004
Patrick W Fedick 1, 2 , Fan Pu 1 , Nicolás M Morato 1 , R Graham Cooks 1
Affiliation  

Fentanyl and its analogues play a major role in the current opioid epidemic. In particular, these highly potent opioids have become a health hazard due to their use as additives in street drugs. Consequently, rapid on-site procedures for the analysis of this class of seized drugs are needed, especially considering the reported backlog of drug samples, which must undergo identification and confirmation tests to validate the presence of an illicit substance. Paper based devices are cheap sampling and analysis vehicles that have been shown capable of allowing rapid identification and confirmation of drugs of abuse. Modifying paper substrates by imprinting nanoparticles enables surface enhanced Raman spectroscopy (SERS) as well as a second analysis from the same substrate, namely paper spray ionization mass spectrometry. While such a procedure has been described for laboratory use, these illicit drug samples are typically collected in the field and this is where testing should be done. We combine paper SERS and paper spray MS on field-portable and commercial off-the-shelf (COTS) devices for the rapid and low-cost identification and confirmation of fentanyl and its analogues, enabling in situ analysis at the point of seizure of suspect samples. The commercial nature of both instruments moves this technology from the academic realm to a setting where the criminal justice system can realistically utilize it. The capabilities of this single-substrate dual-analyzer technique are further examined by sampling a variety of surfaces of forensic interest.

中文翻译:

使用便携式表面增强拉曼光谱和纸喷雾电离质谱法鉴定和确认纸上的芬太尼。

芬太尼及其类似物在当前的阿片类药物流行中起主要作用。特别是,由于这些强效阿片类药物在街头毒品中用作添加剂,已经对健康造成危害。因此,需要一种快速的现场分析此类缉获药物的程序,尤其是考虑到所报告的积压药物样品,必须对其进行鉴定和确认测试以验证非法物质的存在。纸质设备是廉价的采样和分析工具,已被证明能够快速识别和确认滥用药物。通过压印纳米颗粒对纸质基材进行改性,可实现表面增强拉曼光谱(SERS)以及同一基材的第二次分析,即纸浆喷雾电离质谱。尽管已经描述了将这种方法用于实验室的方法,但是这些非法药物样品通常是在现场收集的,应该在此处进行测试。我们将纸质SERS和纸质喷雾MS结合在现场便携式和商用现货(COTS)设备上,以快速,低成本地识别和确认芬太尼及其类似物,从而在缉获可疑物品时进行现场分析样品。两种工具的商业性质都将这项技术从学术领域转移到刑事司法系统可以实际使用它的环境。通过对各种具有法医学意义的表面进行采样,进一步检查了这种单基板双分析仪技术的功能。这些非法药物样品通常是在现场收集的,应该在此处进行测试。我们将纸质SERS和纸质喷雾MS结合在现场便携式和商用现货(COTS)设备上,以快速,低成本地识别和确认芬太尼及其类似物,从而在缉获可疑物品时进行现场分析样品。两种工具的商业性质都将这项技术从学术领域转移到刑事司法系统可以实际使用它的环境。通过对各种具有法医学意义的表面进行采样,进一步检查了这种单基板双分析仪技术的功能。这些非法药物样品通常是在现场收集的,应该在此处进行测试。我们将纸质SERS和纸质喷雾MS结合在现场便携式和商用现货(COTS)设备上,以快速,低成本地识别和确认芬太尼及其类似物,从而在缉获可疑物品时进行现场分析样品。两种工具的商业性质都将这项技术从学术领域转移到刑事司法系统可以实际使用它的环境。通过对各种具有法医学意义的表面进行采样,进一步检查了这种单基板双分析仪技术的功能。我们将纸质SERS和纸质喷雾MS结合在现场便携式和商用现货(COTS)设备上,以快速,低成本地识别和确认芬太尼及其类似物,从而在缉获可疑物品时进行现场分析样品。两种工具的商业性质都将这项技术从学术领域转移到刑事司法系统可以实际使用它的环境。通过对各种具有法医学意义的表面进行采样,进一步检查了这种单基板双分析仪技术的功能。我们将纸质SERS和纸质喷雾MS结合在现场便携式和商用现货(COTS)设备上,以快速,低成本地识别和确认芬太尼及其类似物,从而在缉获可疑物品时进行现场分析样品。两种工具的商业性质都将这项技术从学术领域转移到刑事司法系统可以实际使用它的环境。通过对各种具有法医学意义的表面进行采样,进一步检查了这种单基板双分析仪技术的功能。
更新日期:2020-02-18
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