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Radiotherapy of Parasellar Tumours.
Neuroendocrinology ( IF 4.1 ) Pub Date : 2020-03-04 , DOI: 10.1159/000506902
Luigi Albano 1, 2 , Marco Losa 1 , John Flickinger 3 , Pietro Mortini 1 , Giuseppe Minniti 4, 5
Affiliation  

Parasellar tumours represent a wide group of intracranial lesions, both benign and malignant. They may arise from several structures located within the parasellar area or they may infiltrate or metastasize this region. The treatment of the tumours located in these areas is challenging because of their complex anatomical location and their heterogenous histology. It often requires a multimodal approach, including surgery, radiation therapy (RT), and medical therapy. Due to the proximity of critical structures and the risks of side effects related to the procedure, a successful surgical resection is often not achievable. Thus, RT plays a crucial role in the treatment of several parasellar tumours. Conventional fractionated RT and modern radiation techniques, like stereotactic radiosurgery and proton beam RT, have become a standard management option, in particular for cases with residual or recurrent tumours after surgery and for those cases where surgery is contraindicated. This review examines the role of RT in parasellar tumours analysing several techniques, outcomes and side effects.

中文翻译:

鞍旁肿瘤的放射治疗。

鞍旁肿瘤代表了广泛的颅内病变,包括良性和恶性。它们可能来自位于鞍旁区域内的多个结构,或者它们可能浸润或转移到该区域。位于这些区域的肿瘤的治疗具有挑战性,因为它们具有复杂的解剖位置和异质性组织学。它通常需要多模式方法,包括手术、放射治疗 (RT) 和药物治疗。由于靠近关键结构以及与手术相关的副作用风险,通常无法成功进行手术切除。因此,放疗在几种鞍旁肿瘤的治疗中起着至关重要的作用。传统的分割放疗和现代放射技术,如立体定向放射外科和质子束放疗,已成为标准管理选项,特别是对于手术后有残留或复发肿瘤的病例以及手术禁忌的病例。本综述研究了放疗在鞍旁肿瘤中的作用,分析了几种技术、结果和副作用。
更新日期:2020-03-04
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