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Statins reduce vascular inflammation in atherogenesis: A review of underlying molecular mechanisms.
The International Journal of Biochemistry & Cell Biology ( IF 4 ) Pub Date : 2020-02-29 , DOI: 10.1016/j.biocel.2020.105735
Luca Liberale 1 , Federico Carbone 2 , Fabrizio Montecucco 3 , Amirhossein Sahebkar 4
Affiliation  

Chronic inflammation enhances the detrimental role of dyslipidaemia during atherogenesis. Statins are among the most effective anti-atherosclerotic medications, being able to impact on both cardiovascular morbidity and mortality. Although these molecules have been first described as lipid-lowering medications, several lines of evidence suggest additional benefits through their “pleiotropic” anti-atherosclerotic activities. Specifically, statins can modulate vascular atherosclerotic inflammation by directly improving functions of endothelial cells, vascular smooth muscle cells, platelets, and immune cells. Here, we discuss basic and clinical evidence to provide an update on the molecular mechanisms underlying the protective anti-inflammatory role of statins in atherogenesis.



中文翻译:

他汀类药物减少动脉粥样硬化中的血管炎症:潜在的分子机制综述。

慢性炎症会增强动脉粥样硬化形成过程中血脂异常的有害作用。他汀类药物是最有效的抗动脉粥样硬化药物之一,能够影响心血管疾病的发病率和死亡率。尽管这些分子最初被描述为降血脂药物,但有几条证据表明,它们的“多效性”抗动脉粥样硬化活性具有更多益处。具体而言,他汀类药物可通过直接改善内皮细胞,血管平滑肌细胞,血小板和免疫细胞的功能来调节血管粥样硬化炎症。在这里,我们讨论了基础和临床证据,以提供关于他汀在动脉粥样硬化中的保护性抗炎作用的分子机制的更新。

更新日期:2020-02-29
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