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Glycodelin is internalized by peripheral monocytes.
Journal of Reproductive Immunology ( IF 3.4 ) Pub Date : 2020-02-15 , DOI: 10.1016/j.jri.2020.103102
Young Bae Lee Hansen 1 , Vibeke Myrhøj 1 , Steen Sørensen 1
Affiliation  

Glycodelin is produced by the endometrial cells during the luteal phase and first trimester of pregnancy and plays a role in the regulation of the endometrial immunology. However, the molecular connection between glycodelin and the maternal immune system is not clear. To better understand the possible physiological interaction between the endometrium and the maternal immune system, we investigated (1) whether glycodelin binds to mainly peripheral monocytes, and in case (2) whether the binding to the membrane only depends on the protein backbone or a carbohydrate structure is needed, and in case (3) whether glycodelin is internalized after binding to the membrane. We demonstrated that glycodelin - with or without the carbohydrate structure - was preferentially bound and internalized to peripheral monocytes. Surprisingly, we found signals in the nucleus of the monocytes indicating a potential regulating effect of glycodelin may be exerted through the nucleus. However, further studies should be performed to confirm this finding.

中文翻译:

糖精蛋白被外周单核细胞内在化。

甘草酸在妊娠的黄体期和孕早期由子宫内膜细胞产生,并在子宫内膜免疫学的调节中起作用。然而,糖蛋白与母体免疫系统之间的分子联系尚不清楚。为了更好地了解子宫内膜与母体免疫系统之间可能的生理相互作用,我们研究了(1)糖蛋白是否主要结合于外周单核细胞,以及在情况(2)中,与膜的结合是否仅取决于蛋白质骨架或碳水化合物需要结构,在情况(3)中,糖蛋白在结合到膜上后是否被内化。我们证明,无论有无碳水化合物结构的糖蛋白都优先结合并内在化于外周单核细胞。出奇,我们在单核细胞的核中发现了信号,表明可能通过核发挥了糖精的潜在调节作用。但是,应进行进一步的研究以证实这一发现。
更新日期:2020-02-15
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