Sepsis-associated encephalopathy (SAE) is a significant problem in patients with sepsis, and it is associated with a decrease in cognitive and sensitivity capability induced by systemic inflammation. SAE is implicated in reversible brain damage of several regions related to cognition, emotion, and sensation; however, it is not well established if it could affect brain regions associated with nociceptive modulation. Here were evaluated the nociceptive thresholds in rats with systemic inflammation induced by cecal ligation puncture (CLP). After 24 h of CLP, it was observed an increase in nociceptive threshold in all tests. Periaqueductal gray, rostroventral medulla, critical regions for descending nociceptive modulation, were evaluated and showed enhanced pro-inflammatory cytokines as well as glial activation. These results suggest that systemic inflammation could compromise descending facilitatory pathways, impairing nociceptive sensory functioning.

中文翻译：

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脓毒症诱发的脑病损害大鼠的下行伤害感受通路

脓毒症相关脑病 (SAE) 是脓毒症患者的一个重要问题，它与全身炎症引起的认知和敏感性能力下降有关。SAE 与认知、情绪和感觉相关的几个区域的可逆性脑损伤有关；然而，它是否会影响与伤害感受调制相关的大脑区域还没有得到很好的证实。此处评估了盲肠结扎穿刺 (CLP) 诱导的全身炎症大鼠的伤害感受阈值。CLP 24 小时后，在所有测试中观察到伤害性阈值增加。评估了导水管周围灰色、延髓延髓、下行痛觉调节的关键区域，并显示出增强的促炎细胞因子以及神经胶质激活。