Recent years have seen a great expansion in our knowledge of the roles that metabolites play in cellular signaling. Structural data have provided crucial insights into mechanisms through which amino acids are sensed. New nutrient-coupled protein and RNA modifications have been identified and characterized. A growing list of functions has been ascribed to metabolic regulation of modifications such as acetylation, methylation, and glycosylation. A current challenge lies in developing an integrated understanding of the roles that metabolic signaling mechanisms play in physiology and disease, which will inform the design of strategies to target such mechanisms. In this brief article, we review recent advances in metabolic signaling through post-translational modification during cancer progression, to provide a framework for understanding signaling roles of metabolites in the context of cancer biology and illuminate areas for future investigation.

中文翻译：

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深入了解代谢物是癌症进展中的信号分子。

近年来，我们对代谢物在细胞信号传导中的作用的认识有了很大的扩展。结构数据提供了重要的洞察力，通过这些机制可以检测氨基酸。新的营养耦合蛋白和RNA修饰已得到鉴定和表征。越来越多的功能被归因于修饰的代谢调节，例如乙酰化，甲基化和糖基化。当前的挑战在于对代谢信号机制在生理和疾病中所起的作用的全面理解，这将为针对此类机制的策略设计提供依据。在这篇简短的文章中，我们回顾了癌症进展过程中通过翻译后修饰进行的代谢信号传导的最新进展，