A phytochemical investigation of the root of Angelica dahurica led to the isolation of benzofuran and coumarin derivatives. This is the first report of the isolation and identification of three furanocoumarin sulfates from A. dahurica root. The structures of a total of twelve undescribed compounds were determined by extensive spectroscopic analysis, including 2D NMR data, hydrolysis, and solvolysis, followed by either physicochemical and spectroscopic data or X-ray crystallographic analysis. The isolated compounds were evaluated for their PPAR-γ ligand-binding activity, and six compounds showed significant PPAR-γ ligand-binding activity. In particular, the undescribed benzofuran derivative, 3-[6,7-furano-9-hydroxy-4-(2″,3″-dihydroxy-3″-methylbutyloxy)]-phenyl propionic acid, exhibited the most potent PPAR-γ ligand-binding activity and accumulated intracellular lipid in 3T3-L1 cells.

中文翻译：

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当归根的苯并呋喃和香豆素衍生物及其PPAR-γ配体结合活性

当归根的植物化学研究导致苯并呋喃和香豆素衍生物的分离。这是从 A. dahurica 根中分离和鉴定三种呋喃香豆素硫酸盐的第一份报告。总共十二个未描述的化合物的结构通过广泛的光谱分析确定，包括 2D NMR 数据、水解和溶剂分解，然后是物理化学和光谱数据或 X 射线晶体学分析。对分离出的化合物的 PPAR-γ 配体结合活性进行了评估，6 种化合物表现出显着的 PPAR-γ 配体结合活性。特别地，未描述的苯并呋喃衍生物，3-[6,7-呋喃基-9-羟基-4-(2",3"-二羟基-3"-甲基丁氧基)]-苯基丙酸，