Cryptosporidiosis is one of the most common zoonosis worldwide, causing intestinal infection to both humans and livestock. The purpose of this study was to assess whether the level of anti-C. parvum IgG antibodies transferred through colostrum from dams to newborn calves impacts the susceptibility to cryptosporidiosis. A number of 50 dams and their healthy newborns were included in the study. Colostrum samples were collected within 12 h after birth and anti-C. parvum IgG antibody levels were determined by single radial immunodiffusion. The health condition of the newborns was daily monitored, and fecal samples were collected at first diarrheic episode of a calf. In all dams, the anti-C. parvum IgG antibody concentration in colostrum varied between 570 and 4070 mg/dl; in dams who gave birth to calves with diarrhea and were C. parvum-positive, the antibody concentration in colostrum varied between 680 and 3680 mg/dl (Table 1). The point-biserial correlation showed a negative correlation between the levels of anti-C. parvum antibodies and manifestation of clinical cryptosporidiosis (r=-0.425). Our findings highlight the importance of IgG levels in colostrum received by neonatal calves during their first day of life for prevention of C. parvum infection.

中文翻译：

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初乳IgG抗体水平对预防新生儿乳牛犊中隐孢子虫感染的重要性。

隐孢子虫病是世界上最常见的人畜共患病之一，对人类和牲畜均造成肠道感染。这项研究的目的是评估抗C水平。通过初乳从大坝转移到新生小牛的小IgG抗体影响隐孢子虫病的易感性。研究中包括了50个水坝及其健康的新生儿。初生样品在出生后12小时内收集并抗C。通过单次径向免疫扩散测定小IgG抗体水平。每天监测新生儿的健康状况，并在小牛第一次腹泻发作时收集粪便样品。在所有水坝中，反C。初乳中小IgG抗体浓度在570至4070 mg / dl之间变化。在那些因腹泻而产犊的小水坝中，以及C. parvum阳性的水坝中，初乳中的抗体浓度在680和3680 mg / dl之间变化（表1）。点-二元相关显示抗C水平之间呈负相关。Parvum抗体和临床隐孢子虫病的表现（r = -0.425）。我们的研究结果突显了新生犊牛出生后第一天接受初乳中IgG的水平对预防C. parvum感染的重要性。