Seroprevalence of AIH-related autoantibodies in patients with acute hepatitis E viral infection: a prospective case-control study in China.,Emerging Microbes & Infections

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Seroprevalence of AIH-related autoantibodies in patients with acute hepatitis E viral infection: a prospective case-control study in China.
Emerging Microbes & Infections ( IF 13.2 ) Pub Date : 2020-02-10 , DOI: 10.1080/22221751.2020.1722759
Jian Wu _{1,

2} , Naizhou Guo ₂ , Lifei Zhu ₁ , Xueyan Zhang ₃ , Cunquan Xiong ₃ , Jun Liu ₄ , Yanping Xu ₁ , Jun Fan ₁ , Jiong Yu ₁ , Qiaoling Pan ₁ , Jinfeng Yang ₁ , Hanying Liang ₁ , Xiuyuan Jin ₁ , Sunyi Ye ₁ , Wei Wang ₂ , Chengyuan Liu ₂ , Jinrong Zhang ₅ , Gongqi Li ₆ , Bin Jiang ₇ , Hongcui Cao _{1,

8} , Lanjuan Li ₁

Affiliation

State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
Department of Laboratory Medicine, The First People's Hospital of Yancheng City, Yancheng, People's Republic of China.
Department of Public Health, Jiangsu Vocational College of Medicine, Yancheng, People's Republic of China.
Department of Laboratory Medicine, The Fifth People's Hospital of Wuxi, Affiliated to Jiangnan University, Wuxi, People's Republic of China.
Department of Laboratory Medicine, The People's Hospital of Dafeng City, Yancheng, People's Republic of China.
Department of Clinical Laboratory, Linyi Traditional Hospital, Linyi, People's Republic of China.
Department of Laboratory Medicine, The Central Blood Station of Yancheng City, Yancheng, People's Republic of China.
Zhejiang Provincial Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases, Hangzhou, People's Republic of China.

The seroprevalenc of autoimmune hepatitis (AIH)-related antibodies in patients, particularly Asians, with acute hepatitis E (AHE) is unclear. In this study, we investigated whether acute hepatitis E virus (HEV) infection is associated with the seroprevalence of AIH-related autoantibodies and assessed their impact on the disease characteristics. AIH-related autoantibodies were detected by indirect immunofluorescence in 198 AHE patients and 50 type 1 AIH patients. The positivity rates of against nuclear antigen (ANA) and smooth muscles antibody (SMA) in AHE patients were 37.4% and 22.7%, and the total positivity rate was 50%. Compared to those in AIH patients, the positivity rates of ANA-H and SMA-AA were significantly lower (35.1% vs. 82.1% and 4.4% vs. 88.4%). Female gender and the ALT level, but not immunosuppressive or antiviral drugs, were independently predictive of the presence of AIH-related autoantibodies in AHE patients. Fifty-two patients positive for AIH-related autoantibodies were followed up for 12 months. During this period, 33 of them became negative and 19 remained positive, albeit with significantly decreased titres. In conclusions, the seroprevalence of AIH-related autoantibodies in AHE patients was elevated, particularly in females, but their subspecificities and titres differed from those of type 1 AIH. Acute HEV infection may be related to AIH.Abbreviations: AIH: autoimmune hepatitis; AHE: acute hepatitis E; ANA: against nuclear antigen; SMA: smooth muscles antibody; ANA-H: ANA with homogeneous pattern; SMA-AA: SMA with anti-actin pattern; Anti-LKM1: anti- liver-kidney microsomes-1 antibody; ANCA: anti-neutrophil cytoplasmic antibody; AMA: anti-mitochondrial antibody; Anti-SLA: anti-soluble liver antigen; Anti-LC1: anti-liver cytoplasmic type 1 antibody; pANCA: perinuclear antineutrophil cytoplasmic antibody.

更新日期：2020-02-10

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