Time-restricted feeding (TRF) has been shown to improve body composition, blood lipids, and reduce markers of inflammation and oxidative stress. However, most of these studies come from rodent models and small human samples, and it is not clear if the benefits are dependent upon a caloric deficit, or the time restriction nature of TRF. Based off of previous research, we hypothesized that humans following an ad libitum TRF protocol would reduce caloric intake and this caloric deficit would be associated with greater improvements in cardiometabolic health including blood pressure, body composition, blood lipids, and markers of inflammation and antioxidant status compared to an isocaloric TRF protocol. The purpose of this study was to: (1) examine the impact of TRF on markers of cardio-metabolic health and antioxidant status and (2) determine if the adaptations from TRF would differ under ad libitum compared to isocaloric conditions. Twenty-three healthy men were randomized to either an ad libitum or isocaloric 16:8 (fasting: feeding) TRF protocol. A total of 22 men completed the 28-day TRF protocol (mean ± SD; age: 22 ± 2.5 yrs.; height: 178.4 ± 6.9 cm; weight: 90.3 ± 24 kg; BMI: 28.5 ± 8.3 kg/m2). Fasting blood samples were analyzed for glucose, lipids, as well as adiponectin, human growth hormone, insulin, cortisol, C-reactive protein, superoxide dismutase, total nitrate/nitrite, and glutathione. Time-restricted feeding in both groups was associated with significant (P < .05) reductions in body fat, blood pressure, and significant increases in adiponectin and HDL-c. No changes in caloric intake were detected. In summary, the results from this pilot study in metabolically healthy, active young men, suggest that TRF can improve markers of cardiometabolic health.

中文翻译：

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限时喂养可改善身体活跃的大学年龄男性的心脏代谢健康指标：一项为期 4 周的随机前期试验研究

限时喂养 (TRF) 已被证明可以改善身体成分、血脂，并减少炎症和氧化应激的标志物。然而，这些研究中的大多数来自啮齿动物模型和小型人类样本，目前尚不清楚这些益处是否取决于热量不足或 TRF 的时间限制性质。基于之前的研究，我们假设人类遵循随意的 TRF 协议会减少热量摄入，这种热量不足将与心脏代谢健康的更大改善有关，包括血压、身体成分、血脂以及炎症和抗氧化状态的标志物与等热量 TRF 方案相比。本研究的目的是：(1) 检查 TRF 对心脏代谢健康和抗氧化状态标志物的影响，以及 (2) 确定与等热量条件相比，TRF 的适应性在随意下是否会有所不同。23 名健康男性随机接受随意或等热量 16:8（禁食：喂食）TRF 方案。共有 22 名男性完成了 28 天的 TRF 协议（平均值 ± SD；年龄：22 ± 2.5 岁；身高：178.4 ± 6.9 厘米；体重：90.3 ± 24 公斤；BMI：28.5 ± 8.3 公斤/平方米）。对空腹血样进行葡萄糖、脂质以及脂联素、人类生长激素、胰岛素、皮质醇、C-反应蛋白、超氧化物歧化酶、总硝酸盐/亚硝酸盐和谷胱甘肽的分析。两组的限时喂养都与体脂、血压显着降低（P < .05）以及脂联素和 HDL-c 显着增加相关。没有检测到热量摄入的变化。总之，这项针对代谢健康、活跃的年轻男性的试点研究的结果表明，TRF 可以改善心脏代谢健康的标志物。