Platelet transfusions are commonly administered to treat bleeding in cardiac surgery. The aim of this study was to compare platelet (PLT) count and values of collagen adenosine diphosphate closure time (cADP-CT) measured by Platelet Function Analyzer (PFA) for prediction of PLT transfusion therapy following coronary bypass surgery. For this prospective observational study, 66 patients scheduled for coronary artery bypass grafting (CABG) who received early PLT transfusions (within 60 min after the operation) were enrolled. To assess changes in platelets, count and function, two time points were selected: 15 min before and 30 − 60 min after the end of PLT transfusion. The patients were divided into transfused and non-transfused with further PLT in the 48 h postoperatively. We used the receiver operating characteristics (ROC) curve to investigate whether the PLT count and cADP-CT values were predictors of PLT transfusion. The positive predictive values (PPV) of PLT count and cADP-CT after PLT transfusion for further PLT transfusion were 33% and 86% respectively, with a PLT count threshold of ≤200 × 10⁹/L and cADP-CT threshold of ≥118 s. The comparison among the ROC curves showed a statistical difference (p = .0002). In multiple regression analysis, cADP-CT was the strongest predictor for the number of PLT transfusion doses in the 48 h postoperatively. In CABG patients, the results of cADP-CT after PLT transfusion have a better predictive capacity for further PLT transfusions than the PLT count.

血小板输注通常用于治疗心脏手术中的出血。这项研究的目的是比较血小板（PLT）计数和血小板功能分析仪（PFA）测得的胶原蛋白二磷酸腺苷闭合时间（cADP-CT）的值，以预测冠状动脉搭桥手术后的PLT输注治疗。在这项前瞻性观察研究中，纳入了66例计划进行冠状动脉旁路移植术（CABG）的患者，这些患者接受了早期PLT输血（手术后60分钟内）。为了评估血小板，计数和功能的变化，选择了两个时间点：PLT输注结束前15分钟和结束后30-60分钟。术后48小时将患者分为输血型和非输血型。我们使用接收器操作特征（ROC）曲线来调查PLT计数和cADP-CT值是否是PLT输血的预测指标。PLT输血和进一步输注PLT后cADP-CT的阳性预测值（PPV）分别为33％和86％，PLT计数阈值≤200×10⁹ / L和cADP-CT阈值≥118s。ROC曲线之间的比较显示出统计学差异（p  = .0002）。在多元回归分析中，cADP-CT是术后48小时内PLT输注剂量数量的最强预测指标。在CABG患者中，与PLT计数相比，PLT输注后cADP-CT的结果对进一步PLT输注具有更好的预测能力。