Hyperglycemia induces vascular dysfunction that is thought to be initiated by neutrophils. Neutrophil activation produces endothelial injury by pathways that include NETosis, a type of specific cell death. In this study, we investigated the effects of hyperglycemia on neutrophil activation, cell death, NETosis, and endothelial glycocalyx damage using a mouse diabetes model.

中文翻译：

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高血糖对 2 型糖尿病小鼠模型中性粒细胞胞外陷阱形成和内皮糖萼损伤的影响。

高血糖引起血管功能障碍，这被认为是由中性粒细胞引起的。中性粒细胞激活通过包括 NETosis（一种特定细胞死亡）在内的途径产生内皮损伤。在这项研究中，我们使用小鼠糖尿病模型研究了高血糖对中性粒细胞活化、细胞死亡、NETosis 和内皮糖萼损伤的影响。