Nowadays, the interest in the role of dietary components able to influence the composition and the activity of the intestinal microbiota and, consequently, to modulate the risk of genotoxicity and colon cancer is increasing in the scientific community. Within this topic, the microbial ability to have a protective role at gastrointestinal level by counteracting the biological activity of genotoxic compounds, and thus preventing the DNA damage, is deemed important in reducing gut pathologies and is considered a new tool for probiotics and functional foods. A variety of genotoxic compounds can be found in the gut and, besides food-related mutagens and other DNA-reacting compounds, there is a group of pollutants commonly used in food packaging and/or in thousands of everyday products called endocrine disruptors (EDs). EDs are exogenous substances that alter the functions of the endocrine system through estrogenic and anti-estrogenic activity, which interfere with normal hormonal function in human and wildlife. Thus, this paper summarizes the main applications of probiotics, mainly lactobacilli, as a bio-protective tool to counteract genotoxic and mutagenic agents, by biologically inhibiting the related DNA damage in the gut, and highlights the emerging perspectives to enlarge and further investigate the microbial bio-protective role at intestinal level.

中文翻译：

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益生菌抗原毒性作为 DNA 生物保护工具的活性：以内分泌干扰物为重点的小型综述。

如今，科学界对饮食成分能够影响肠道微生物群的组成和活性，从而调节遗传毒性和结肠癌风险的作用越来越感兴趣。在本主题中，微生物通过抵消基因毒性化合物的生物活性从而防止 DNA 损伤在胃肠道水平发挥保护作用的能力被认为在减少肠道病变方面很重要，并且被认为是益生菌和功能性食品的新工具。在肠道中可以发现多种遗传毒性化合物，除了与食物相关的诱变剂和其他与 DNA 反应的化合物外，还有一组常用于食品包装和/或成千上万的日常用品中的污染物，称为内分泌干扰物 (EDs) . ED是通过雌激素和抗雌激素活性改变内分泌系统功能的外源性物质，干扰人类和野生动物的正常激素功能。因此，本文总结了益生菌（主要是乳酸杆菌）的主要应用，作为一种生物保护工具，通过生物抑制肠道中相关的 DNA 损伤来对抗基因毒性和诱变剂，并强调了扩大和进一步研究微生物的新观点。肠道水平的生物保护作用。