Antimicrobials have undoubtedly improved the lives of people with CF, but important antimicrobial-related toxicities and the emergence of antimicrobial-resistant bacteria associated with their use must be considered. Antimicrobial stewardship (AMS) is advocated across the spectrum of healthcare to promote the appropriate use of antimicrobials to preserve their current effectiveness and to optimise treatment, and it is clear that AMS strategies are applicable to and can benefit both non-CF and CF populations. This perspective explores the definition and components of an AMS program, the current evidence for AMS, and the reasons why AMS is a challenging concept in the provision of CF care. We also discuss the elements of CF care which align with AMS programs and principles and propose research priorities for AMS in CF.

中文翻译：

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寻找抗生素管理与囊性纤维化的相关性

抗生素无疑改善了 CF 患者的生活，但必须考虑到重要的抗生素相关毒性以及与其使用相关的抗生素耐药细菌的出现。抗菌药物管理 (AMS) 在整个医疗保健领域得到提倡，以促进抗菌药物的适当使用，以保持其当前的有效性并优化治疗，很明显，AMS 策略适用于非 CF 和 CF 人群，并且可以从中受益。这个观点探讨了 AMS 计划的定义和组成部分、AMS 的当前证据，以及 AMS 在提供 CF 护理方面是一个具有挑战性的概念的原因。我们还讨论了与 AMS 计划和原则相一致的 CF 护理要素，并提出了 CF 中 AMS 的研究重点。