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Antimicrobial susceptibility of Trueperella pyogenes isolated from food-producing ruminants.
Veterinary Microbiology ( IF 3.3 ) Pub Date : 2020-01-22 , DOI: 10.1016/j.vetmic.2020.108593
Ángela Galán-Relaño 1 , Lidia Gómez-Gascón 1 , Belén Barrero-Domínguez 2 , Inmaculada Luque 1 , Francisco Jurado-Martos 3 , Ana I Vela 4 , Celia Sanz-Tejero 5 , Carmen Tarradas 1
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A total of 96 Trueperella pyogenes isolates, an opportunistic pathogen of food-producing ruminants, obtained from cattle (n = 34), sheep (n = 35) and goats (n = 27), and identified by Real Time PCR (qPCR), were analysed to determine the susceptibility to 12 antimicrobials commonly used in livestock, using a broth microdilution. The Minimal Inhibitory Concentration (MIC) distribution was unimodal for half of the antimicrobials tested with the exception of apramycin, gentamicin, streptomycin, oxytetracycline, tylosin, and erythromycin all of which showed bimodal MIC distributions. Low MIC90 values for penicillin, amoxicillin, ceftiofur, enrofloxacin, and gentamicin (<1 μg/ml) were obtained, suggesting that these antimicrobials would be the most effective first line empiric treatment for T. pyogenes infections in livestock. Furthermore, according to the specific T. pyogenes breakpoints for penicillin, sulfamethoxazole/trimethoprim and erythromycin, 93.7 % of isolates were susceptible to penicillin and 77.2 % to erythromycin, whereas 92.7 % were non-susceptible to sulfamethoxazole/trimethoprim. Significant differences were observed in the MIC distribution of almost all antimicrobials, except enrofloxacin, tylosin and erythromycin against cattle, sheep or goat isolates, although all antimicrobials showed similar MIC90 values, except apramycin and oxytetracycline that showed higher values when tested against cattle isolates. These data provide interesting information on the antimicrobials of choice for the treatment of infections caused by T. pyogenes in ruminants.

中文翻译:

从食品反刍动物中分离出的化脓性疟原虫的药敏性。

从牛(n = 34),绵羊(n = 35)和山羊(n = 27)获得的总共96种化脓性Truperella pyogenes分离物是产生食物的反刍动物的机会病原体,并通过实时PCR(qPCR)进行了鉴定,使用肉汤微稀释液进行分析,以确定对家畜中常用的12种抗菌素的敏感性。除阿普霉素,庆大霉素,链霉素,土霉素,泰乐菌素和红霉素外,其余一半的抗菌药物的最低抑菌浓度(MIC)均为单峰分布,所有这些都显示出双峰MIC分布。青霉素,阿莫西林,头孢噻呋,恩氟沙星和庆大霉素的MIC90值均较低(<1μg/ ml),这表明这些抗微生物剂将是家畜化脓性链球菌感染的最有效的一线经验治疗。此外,根据青霉素,磺胺甲恶唑/甲氧苄氨嘧啶和红霉素的特定化脓性支原体断裂点,分离株对青霉素敏感,占93.7%,对红霉素敏感,而对磺胺甲恶唑/甲氧苄啶则不敏感的占92.7%。除了恩诺沙星,泰乐菌素和红霉素对牛,绵羊或山羊分离株的抗菌作用外,几乎所有抗菌剂的MIC分布都有显着差异,尽管除阿普霉素和土霉素外,所有抗微生物剂对牛,绵羊或山羊分离株的MIC90值均相近。这些数据为治疗反刍动物化脓性链球菌引起的感染所选择的抗菌剂提供了有趣的信息。7%的分离株对青霉素敏感,而77.2%对红霉素敏感,而92.7%对磺胺甲恶唑/甲氧苄啶不敏感。除了恩诺沙星,泰乐菌素和红霉素对牛,绵羊或山羊分离株的抗菌作用外,几乎所有抗菌素的MIC分布都有显着差异,尽管除阿普霉素和土霉素外,所有抗微生物剂对牛,绵羊或山羊分离株的MIC90值均相近。这些数据为治疗反刍动物化脓性链球菌引起的感染所选择的抗菌剂提供了有趣的信息。7%的分离株对青霉素敏感,而77.2%对红霉素敏感,而92.7%对磺胺甲恶唑/甲氧苄啶不敏感。除了恩诺沙星,泰乐菌素和红霉素对牛,绵羊或山羊分离株的抗菌作用外,几乎所有抗菌剂的MIC分布都有显着差异,尽管除阿普霉素和土霉素外,所有抗微生物剂对牛,绵羊或山羊分离株的MIC90值均相近。这些数据为治疗反刍动物化脓性链球菌引起的感染所选择的抗菌剂提供了有趣的信息。除了恩诺沙星,泰乐菌素和红霉素对牛,绵羊或山羊分离株的抗药性,尽管所有抗微生物剂的MIC90值均相近,但阿普霉素和土霉素对牛分离株的检测值较高。这些数据为治疗反刍动物化脓性链球菌引起的感染所选择的抗菌剂提供了有趣的信息。除了针对牛,绵羊或山羊分离株的恩诺沙星,泰乐菌素和红霉素外,尽管所有抗生素均显示相似的MIC90值,但阿普霉素和土霉素对牛分离株进行测试时显示出更高的MIC90值。这些数据为治疗反刍动物化脓性链球菌引起的感染所选择的抗菌剂提供了有趣的信息。
更新日期:2020-01-22
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